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Titolo:
Parkin and the molecular pathways of Parkinson's disease
Autore:
Giasson, BI; Lee, VMY;
Indirizzi:
Univ Penn, Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 t Dis Res, Philadelphia, PA 19104 USA
Titolo Testata:
NEURON
fascicolo: 6, volume: 31, anno: 2001,
pagine: 885 - 888
SICI:
0896-6273(20010927)31:6<885:PATMPO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
UBIQUITIN-PROTEIN LIGASE; RECESSIVE JUVENILE PARKINSONISM; GENE; NEUROPATHOLOGY; MUTATIONS; FAMILY; ONSET;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, VMY Univ Penn, Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat DisRes, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 , Philadelphia, PA 19104 USA
Citazione:
B.I. Giasson e V.M.Y. Lee, "Parkin and the molecular pathways of Parkinson's disease", NEURON, 31(6), 2001, pp. 885-888

Abstract

Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implicatedin the biochemical pathways underlying the etiology of sporadic PD. Mutations in the parkin gene causal of autosomal recessive juvenile parkinsonism highlight that ubiquitin-mediated proteolysis may play an important role inthe pathobiology of PD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:36:38