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Titolo:
Potentiation of interleukin-1 beta adjuvant effects on the humoral immune response to antigen in adrenalectomized mice
Autore:
Kusnecov, AW; Rossi-George, A;
Indirizzi:
Rutgers State Univ, Dept Psychol, Biopsychol & Behav Neurosci Program, Piscataway, NJ 08855 USA Rutgers State Univ Piscataway NJ USA 08855 gram, Piscataway, NJ 08855 USA
Titolo Testata:
NEUROIMMUNOMODULATION
fascicolo: 2, volume: 9, anno: 2001,
pagine: 109 - 118
SICI:
1021-7401(2001)9:2<109:POIBAE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING FACTOR; NEURO-ENDOCRINE; RAT HYPOTHALAMUS; IN-VIVO; SUPPRESSION; SECRETION; NOREPINEPHRINE; SYSTEM; ACTIVATION;
Keywords:
interleukin-1 beta; interleukin-6; adrenalectomy; antibody; ovalbumin; hypothalamic-pituitary-adrenal axis glucocorticoids; psychoneuroimmunology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kusnecov, AW Rutgers State Univ, Dept Psychol, Biopsychol & Behav NeurosciProgram, 152Frelinghuysen Rd, Piscataway, NJ 08855 USA Rutgers State Univ 152 Frelinghuysen Rd Piscataway NJ USA 08855
Citazione:
A.W. Kusnecov e A. Rossi-George, "Potentiation of interleukin-1 beta adjuvant effects on the humoral immune response to antigen in adrenalectomized mice", NEUROIMMUNO, 9(2), 2001, pp. 109-118

Abstract

Objectives: Activation of the hypothalamic-pituitary-adrenal (HPA) axis isa primary effect of interleukin-1 (IL-1), with elevated glucocorticoids considered a mechanism for negative feedback immunoregulation. However, thereis little direct evidence of such a functional relationship between IL-1-mediated immunoregulation and neuroendocrine influences elicited by IL-1. Therefore, the goal of this study was to examine whether the known adjuvant effects of IL-1 are altered in the absence of neuroendocrine feedback due toadrenalectomy. Methods: Male BALB/c mice subjected to adrenalectomy (ADX) or sham surgery were administered with saline or recombinant human IL-1 beta (rhIL-1 beta) and at the same time immunized with 100 mug ovalbumin (OVA). In vivo and in vitro measures of antigen-specific IgG antibody production, IL-6 production and spleen cell proliferation were taken 6 and 12 days later. Results: It was demonstrated that administration of rhIL-1 beta at a dose that activates the HPA axis resulted in a significant augmentation of serum anti-OVA IgG antibody levels. Interestingly, this augmentation was potentiated in ADX animals. In addition, the in vitro spleen cell memory IgG antibody response to OVA was significantly augmented in rhIL-1 beta -treatedanimals, and again, further potentiated in ADX animals. Interestingly, while hrIL-1 beta treatment augmented antigen-stimulated IL-6 production - suggesting an effect of IL-1 on antigen-specific T helper 2 cell memory formation potentiation was not evident in ADX animals. Conclusions: These resultsare consistent with the concept of HPA axis-mediated neuroendocrine feedback on excessive immune responsiveness due to IL-1. Such feedback may prevent disturbances to the self-limiting functions of the immune system, which are important to the prevention of autoimmune diseases, some of which involve elevated IL-1 production. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:08:18