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Titolo:
Strain differences in the expression of corticotropin-releasing hormone immunoreactivity in nerves that supply the spleen and thymus
Autore:
Bellinger, DL; Brouxhon, SM; Lubahn, C; Tran, L; Kang, JI; Felten, DL; Lorton, D;
Indirizzi:
Loma Linda Univ, Sch Med, Ctr Neuroimmunol, Loma Linda, CA 92352 USA Loma Linda Univ Loma Linda CA USA 92352 immunol, Loma Linda, CA 92352 USA Univ Rochester, Emergency Dept, Rochester, NY 14627 USA Univ Rochester Rochester NY USA 14627 gency Dept, Rochester, NY 14627 USA Sun Hlth Res Inst, Hoover Arthrit Res Ctr, Sun City, AZ USA Sun Hlth Res Inst Sun City AZ USA over Arthrit Res Ctr, Sun City, AZ USA
Titolo Testata:
NEUROIMMUNOMODULATION
fascicolo: 2, volume: 9, anno: 2001,
pagine: 78 - 87
SICI:
1021-7401(2001)9:2<78:SDITEO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL POLYPEPTIDE VIP; ADJUVANT-INDUCED ARTHRITIS; SECONDARY LYMPHOID ORGANS; SUBSTANCE-P INNERVATION; MAST-CELL DEGRANULATION; NERVOUS-SYSTEM; RAT SPLEEN; VASCULAR LEAKAGE; FACTOR RECEPTORS; BETA-ENDORPHIN;
Keywords:
neural-immune interactions; corticotropin-releasing hormone; innervation; lymphoid organs; spleen; rat; strain differences;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Bellinger, DL Loma Linda Univ, Sch Med, Ctr Neuroimmunol, 11021 Campus St,Loma Linda, CA 92352 USA Loma Linda Univ 11021 Campus St Loma Linda CA USA92352 USA
Citazione:
D.L. Bellinger et al., "Strain differences in the expression of corticotropin-releasing hormone immunoreactivity in nerves that supply the spleen and thymus", NEUROIMMUNO, 9(2), 2001, pp. 78-87

Abstract

The existence of nerve fibers containing corticotropin-releasing hormone (CRH) immunoreactivity in primary and secondary lymphoid organs from three strains of young adult male rats was examined. Spleens and thymuses from Fischer 344 (F344), Sprague-Dawley (SD) and Lewis (LEW) rats were prepared forimmunocytochemistry using antisera directed against CRH. In F344 and SD rats, we were unable to demonstrate CRH-immunoreactive nerves in either the thymus or the spleen. Despite the lack of CRH-containing nerves, CRH immunoreactivity was present in pleotropic cells in the septum, cortex and medullaof the thymus, and in the red and white pulp of spleens from F344 and SD rats. In contrast, CRH+ nerves were found in thymuses and spleens from LEW rats. CRH+ nerves coursed in the interlobular septa, capsule, cortex and medulla of the LEW rat thymus. Large CRH-immunoreactive nerve bundles were present in the hilar region of the LEW rat spleen, and individual CRH+ fibers coursed in the capsule, trabeculae, red pulp, venous sinuses and marginal zone of the white pulp of the spleen. These findings indicate strain differences in neurotransmitter-specific nerves that innervate the rat spleen and thymus under basal conditions. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:25:45