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Titolo:
NXT-associated markers and perforin in hyperplastic thymuses from patientswith myasthenia gravis
Autore:
Nagane, Y; Utsugisawa, K; Obara, D; Tohgi, H;
Indirizzi:
Iwate Med Univ, Dept Neurol, Morioka, Iwate 02085805, Japan Iwate Med Univ Morioka Iwate Japan 02085805 orioka, Iwate 02085805, Japan
Titolo Testata:
MUSCLE & NERVE
fascicolo: 10, volume: 24, anno: 2001,
pagine: 1359 - 1364
SICI:
0148-639X(200110)24:10<1359:NMAPIH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NK1.1(+) T-CELLS; ACETYLCHOLINE-RECEPTOR; CD44; LYMPHOCYTES; ACTIVATION; SUBPOPULATION; ADHESION;
Keywords:
CD44; myasthenia gravis; NKT cells; perforin; thymus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Tohgi, H Iwate Med Univ, Dept Neurol, 19-1 Uchimaru, Morioka, Iwate 02085805, Japan Iwate Med Univ 19-1 Uchimaru Morioka Iwate Japan 02085805 , Japan
Citazione:
Y. Nagane et al., "NXT-associated markers and perforin in hyperplastic thymuses from patientswith myasthenia gravis", MUSCLE NERV, 24(10), 2001, pp. 1359-1364

Abstract

Immunohistochemical expression of natural killer T (NKT) cell-associated markers (V alpha 24 and CD56) and perforin in relation to CD44-highly positive (CD44(high)) cells was studied in hyperplastic thymuses from patients with myasthenia gravis (MG) whose symptoms dramatically improved after thymectomy and compared with non-MG control thymuses. In the control thymuses, V alpha 24-positive (V alpha 24(+)) and CD56-positive (CD56(+)) cells were sparsely distributed in the medullary area only. In contrast, in hyperplasticMG thymus, V alpha 24(+) and CD56+ cells were more frequent in connective tissue, appeared to have penetrated the thymic parenchyma, and most coexpressed CD44 high. Perforin-positive cells were not present in the control thymus, but were in the connective tissue and perilobular cortical areas in the hyperplastic MG thymus. Most of these perforin-positive cells were CD44 high and were located near blood vessels. They appeared to have migrated directly from the vascular system and penetrated the thymic parenchyma. Some perforin-positive cells coexpressed V alpha 24, CD56, or both. These findings suggest that in this particular type of MG thymus, NKT-like cells may have increased via a CD44- and perforin-mediated mechanism, leading to an imbalance in the immune system that favored an antibody-mediated autoimmunity against the acetylcholine receptor. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 20:49:42