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Titolo:
Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor
Autore:
Fribourg, S; Braun, IC; Izaurralde, E; Conti, E;
Indirizzi:
European Mol Biol Lab, D-69117 Heidelberg, Germany European Mol Biol Lab Heidelberg Germany D-69117 117 Heidelberg, Germany
Titolo Testata:
MOLECULAR CELL
fascicolo: 3, volume: 8, anno: 2001,
pagine: 645 - 656
SICI:
1097-2765(200109)8:3<645:SBFTRO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPORT; CONSTITUTIVE TRANSPORT ELEMENT; PORE COMPLEX; TAP REVEALS; PROTEIN; IMPORT; BINDING; MEX67P; NTF2; INTERACTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Conti, E European Mol Biol Lab, Meyerhofstr 1, D-69117 Heidelberg, GermanyEuropean Mol Biol Lab Meyerhofstr 1 Heidelberg Germany D-69117 y
Citazione:
S. Fribourg et al., "Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor", MOL CELL, 8(3), 2001, pp. 645-656

Abstract

TAP-p15 heterodimers have been implicated in the export of mRNAs through nuclear pore complexes (NPCs). We report a structural analysis of the interaction domains of TAP and p15 in a ternary complex with a Phe-Gly (FG) repeat of an NPC component. The TAP-p15 heterodimer is structurally similar to the homodimeric transport factor NTF2, but unlike NTF2, it is incompatible with either homodimerization or Ran binding. The NTF2-like heterodimer functions as a single structural unit in recognizing an FG repeat at a hydrophobic pocket present only on TAP and not on p15. This FG binding site interacts synergistically with a second site at the C terminus of TAP to mediate mRNA transport through the pore. In general, our findings suggest that FG repeats bind with a similar conformation to different classes of transport factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:36:50