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Titolo:
Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8
Autore:
Desagher, S; Osen-Sand, A; Montessuit, S; Magnenat, E; Vilbois, F; Hochmann, A; Journot, L; Antonsson, B; Martinou, JC;
Indirizzi:
CNRS, UPR 9023, Montpellier, France CNRS Montpellier FranceCNRS, UPR 9023, Montpellier, France Serono Pharmaceut Res Inst, Plan Les Ouates, Switzerland Serono PharmaceutRes Inst Plan Les Ouates Switzerland tes, Switzerland Dept Cell Biol, Geneva, Switzerland Dept Cell Biol Geneva SwitzerlandDept Cell Biol, Geneva, Switzerland
Titolo Testata:
MOLECULAR CELL
fascicolo: 3, volume: 8, anno: 2001,
pagine: 601 - 611
SICI:
1097-2765(200109)8:3<601:POBBCK>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN PHOSPHATASE 2A; CYTOCHROME-C RELEASE; JURKAT T-CELLS; KAPPA-B-ALPHA; MEDIATED APOPTOSIS; DEATH AGONIST; RECEPTOR; PATHWAYS; MITOCHONDRIA; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Desagher, S CNRS, UPR 9023, Montpellier, France CNRS Montpellier FranceCNRS, UPR 9023, Montpellier, France
Citazione:
S. Desagher et al., "Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8", MOL CELL, 8(3), 2001, pp. 601-611

Abstract

Bid plays an essential role in Fas-mediated apoptosis of the so-called type II cells. In these cells, following cleavage by caspase 8, the C-terminalfragment of Bid translocates to mitochondria and triggers the release of apoptogenic factors, thereby inducing cell death. Here we report that Bid isphosphorylated by casein kinase I (CKI) and casein kinase II (CKII). Inhibition of CKI and CKII accelerated Fas-mediated apoptosis and Bid cleavage, whereas hyperactivity of the kinases delayed apoptosis. When phosphorylated, Bid was insensitive to caspase 8 cleavage in vitro. Moreover, a mutant ofBid that cannot be phosphorylated was found to be more toxic than wild-type Bid. Together, these data indicate that phosphorylation of Bid representsa new mechanism whereby cells control apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 03:58:48