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Titolo:
Reconstitution of a functional core polycomb repressive complex
Autore:
Francis, NJ; Saurin, AJ; Shao, ZH; Kingston, RE;
Indirizzi:
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Mol Biol, Boston, MA 02114 USA Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ch Med, Dept Genet, Boston, MA 02115 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 3, volume: 8, anno: 2001,
pagine: 545 - 556
SICI:
1097-2765(200109)8:3<545:ROAFCP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATIN REMODELING COMPLEX; CHROMOSOME-BINDING-SITES; YEAST SWI/SNF COMPLEX; GROUP PROTEINS; GROUP GENES; TRANSCRIPTIONAL REPRESSION; DROSOPHILA-MELANOGASTER; SWI-SNF; TRITHORAX; ENCODES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Kingston, RE Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 ton, MA 02114 USA
Citazione:
N.J. Francis et al., "Reconstitution of a functional core polycomb repressive complex", MOL CELL, 8(3), 2001, pp. 545-556

Abstract

The opposing actions of polycomb (PcG) and trithorax group (trxG) gene products maintain essential gene expression patterns during Drosophila development. PcG proteins are thought to establish repressive chromatin structures, but the mechanisms by which this occurs are not known. Polycomb repressive complex 1 (PRC1) contains several PcG proteins and inhibits chromatin remodeling by trxG-related SWI/SNF complexes. We have defined a functional core of PRC1 by reconstituting a stable complex using four recombinant PcG proteins. One subunit, PSC, can also inhibit chromatin remodeling on its own. These PcG proteins create a chromatin structure that has normal nucleosome organization and is accessible to nucleases but excludes hSWI/SNF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:19:01