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Titolo:
Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions
Autore:
Xiao, H; Sandaltzopoulos, R; Wang, HM; Hamiche, A; Ranallo, R; Lee, KM; Fu, DG; Wu, C;
Indirizzi:
NCI, Mol Cell Biol Lab, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Mol Cell Biol Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 3, volume: 8, anno: 2001,
pagine: 531 - 543
SICI:
1097-2765(200109)8:3<531:DFOLNS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATIN-REMODELING COMPLEX; GLUTAMINE-RICH DOMAIN; HISTONE-FOLD PROTEINS; YEAST SWI/SNF COMPLEX; DNA-BINDING DOMAIN; GAGA FACTOR; SACCHAROMYCES-CEREVISIAE; HIGH-AFFINITY; IN-VITRO; ISWI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, C NCI, Mol Cell Biol Lab, NIH, Bldg 37,Room 6068, Bethesda, MD 20892 USA NCI Bldg 37,Room 6068 Bethesda MD USA 20892 , Bethesda, MD 20892 USA
Citazione:
H. Xiao et al., "Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions", MOL CELL, 8(3), 2001, pp. 531-543

Abstract

NURF is an ISWI complex of four proteins that uses the energy of ATP hydrolysis to catalyze nucleosome sliding. Three NURF components have been identified previously. We have cloned cDNA encoding the largest NURF subunit, revealing a 301 kDa polypeptide (NURF301) that shares structural motifs with ACF1. We have reconstituted full and partial NURF complexes from recombinant proteins and show that NURF301 and the ISWI ATPase are necessary and sufficient for accurate and efficient nucleosome sliding. An HMGA/HMGI(Y)-like domain of NURF301 that facilitates nucleosome sliding indicates the importance of DNA conformational changes in the sliding mechanism. NURF301 also shows interactions with sequence-specific transcription factors, providing a basis for targeted recruitment of the NURF complex to specific genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:43:19