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Titolo:
Mosaic structure of the DNA molecules of the human chromosomes 21 and 22
Autore:
Haring, D; Kypr, J;
Indirizzi:
Acad Sci Czech Republ, Inst Biophys, CZ-61265 Brno, Czech Republic Acad Sci Czech Republ Brno Czech Republic CZ-61265 Brno, Czech Republic
Titolo Testata:
MOLECULAR BIOLOGY REPORTS
fascicolo: 1, volume: 28, anno: 2001,
pagine: 9 - 17
SICI:
0301-4851(200103)28:1<9:MSOTDM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASYMMETRIC SUBSTITUTION PATTERNS; NUCLEOTIDE-SEQUENCE; ESCHERICHIA-COLI; STRAND ASYMMETRIES; CHLOROPLAST GENOME; CODON USAGE; AIDS VIRUS; GENE; BIAS; DISTRIBUTIONS;
Keywords:
chromosome domains; cluster analysis; correlations; nucleotide distributions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Kypr, J Acad Sci Czech Republ, Inst Biophys, Kralovopolska 135, CZ-61265 Brno, Czech Republic Acad Sci Czech Republ Kralovopolska 135 Brno Czech Republic CZ-61265
Citazione:
D. Haring e J. Kypr, "Mosaic structure of the DNA molecules of the human chromosomes 21 and 22", MOL BIOL RP, 28(1), 2001, pp. 9-17

Abstract

We calculated nucleotide distribution curves along the DNA molecules of the human chromosomes 21 and 22, their correlations in more than 10 000 equidistant positions, and subjected the correlations to cluster analysis. The cluster analysis demonstrated that both DNA molecules were composed of two types of segments exhibiting qualitatively different correlations. The segments differed most in the correlation of the distribution curves of cytosineand guanine, which was very high in type I segments but weak in type II segments. The type I and II segments also significantly differed in the correlations of the distribution curves of adenine with thymine. In addition, adenine strongly anticorrelated with cytosine but this anticorrelation was uniform along both chromosomes and, therefore, it did not contribute to the distinction of the two types of segments. The segments were up to 100 kbp long but they had nothing in common with isochores. Building blocks of the mosaic structure of the DNA molecules of the human chromosomes 21 and 22 are very similar but different in several interesting aspects from those of E. coli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:29:23