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Titolo:
The role of 3'-' untranslated region (3 '-UTR) mediated mRNA stability in cardiovascular pathophysiology
Autore:
Misquitta, CM; Iyer, VR; Werstiuk, ES; Grover, AK;
Indirizzi:
McMaster Univ, Dept Med, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 ed, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Dept Biol, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada r Univ, Dept Biol, Hamilton, ON, Canada
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 224, anno: 2001,
pagine: 53 - 67
SICI:
0300-8177(2001)224:1-2<53:TRO3UR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-BINDING-PROTEIN; NITRIC-OXIDE SYNTHASE; RECEPTOR MESSENGER-RNA; AU-RICH ELEMENT; VASCULAR SMOOTH-MUSCLE; NECROSIS-FACTOR-ALPHA; AGONIST-INDUCED DESTABILIZATION; 3'-UNTRANSLATED REGION; HEART-FAILURE; IN-VITRO;
Keywords:
myocardial infarction; heart failure; hypertension; hypoxia; adrenergic receptors; nitric oxide synthase; endothelium; vascular; RNA stability; gene expression;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
124
Recensione:
Indirizzi per estratti:
Indirizzo: Grover, AK McMaster Univ, Dept Med, 1200 Main St W, Hamilton, ON L8N 3Z5, Canada McMaster Univ 1200 Main St W Hamilton ON Canada L8N 3Z5 Canada
Citazione:
C.M. Misquitta et al., "The role of 3'-' untranslated region (3 '-UTR) mediated mRNA stability in cardiovascular pathophysiology", MOL C BIOCH, 224(1-2), 2001, pp. 53-67

Abstract

Knowledge of transcription and translation has advanced our understanding of cardiac diseases. Here, we present the hypothesis that the stability of mRNA mediated by the 3'-untranslated region (3'-UTR) plays a role in changing gene expression in cardiovascular pathophysiology. Several proteins thatbind to sequences in the 3'-UTR of mRNA of cardiovascular targets have been identified. The affected mRNAs include those encoding beta -adrenergic receptors, angiotensin II receptors, endothelial and inducible nitric oxide synthases, cyclooxygenase, endothelial growth factor, tissue necrosis factor(TNF-alpha), globin, elastin, proteins involved in cell cycle regulation, oncogenes, cytokines and lymphokines. We discuss: (a) the types of 3'-UTR sequences involved in mRNA stability, (b) AUF1, HuR and other proteins that bind to these sequences to either stabilize or destabilize the target mRNAs, and (c) the potential role of the 3'-UTR mediated mRNA stability in heartfailure, myocardial infarction and hypertension. We hope that these concepts will aid in better understanding cardiovascular diseases and in developing new therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:35:21