Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Quantitave and qualitative interferences of pentoxifillyne on hepatic Schistosoma mansoni granulomas: Effects on extracellular matrix and eosinophil population
Autore:
Reis, LF; Ventura, TG; Souza, SO; Arana-Pino, A; Pelajo-Machado, M; Pereira, MJS; Lenzi, HL; Conceicao, MJ; Takiya, CM;
Indirizzi:
Univ Fed Rio de Janeiro, Fac Med, BR-24921590 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-24921590 BCeiro, Brazil Univ Fed Rio de Janeiro, Hosp Clementino Fraga Filho, Serv Anat Patol, BR-24921590 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-24921590 BCeiro, Brazil Inst Oswaldo Cruz, Dept Patol, BR-20001 Rio De Janeiro, Brazil Inst Oswaldo Cruz Rio De Janeiro Brazil BR-20001 Rio De Janeiro, Brazil Inst Oswaldo Cruz, Dept Trop Med, BR-20001 Rio De Janeiro, Brazil Inst Oswaldo Cruz Rio De Janeiro Brazil BR-20001 Rio De Janeiro, Brazil
Titolo Testata:
MEMORIAS DO INSTITUTO OSWALDO CRUZ
, volume: 96, anno: 2001, supplemento:, S
pagine: 107 - 112
SICI:
0074-0276(2001)96:<107:QAQIOP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; STELLATE CELLS; GROWTH-FACTOR; COLLAGEN-SYNTHESIS; MAST-CELLS; TNF-ALPHA; PENTOXIFYLLINE; MICE; MYOFIBROBLASTS; INTERLEUKIN-5;
Keywords:
mast cell; eosinophil; collagen; pentoxifylline; Schistosoma mansoni;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Takiya, CM Univ Fed Rio de Janeiro, Fac Med, BR-24921590 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-24921590 BCl
Citazione:
L.F. Reis et al., "Quantitave and qualitative interferences of pentoxifillyne on hepatic Schistosoma mansoni granulomas: Effects on extracellular matrix and eosinophil population", MEM I OSW C, 96, 2001, pp. 107-112

Abstract

Mast cells and eosinophils actively participate in tissue repair and are prominent components of Schistosoma mansoni granulomas. Since pentoxifillyne(PTA) is an immunomodulatory and antifibrotic substance, we aimed to characterize, by morphological techniques, the effect of this drug on fibrosis developed inside murine hepatic schistosomal granulomatous reaction, beyond the quantification of eosinophil and mast cell populations. The drug (1 mg/100 g animal weight) was administrated from 35 to 90 days post-infection, when the animals were killed. The intragranulomatous interstitial collagen network was analyzed by confocal laser scanning microscopy, the number of eosinophils and mast cells was quantified and the results were validated by t-student test. Treatment did not interfere on the granuloma evolution but caused a significant decrease in the total and involutive number of hepatic granulomas (p = 0.01 and 0.001, respectivelly), and in the intragranulomatous accumulation of eosinophils (p = 0.0001). Otherwise, the number of mast cells was not significantly altered (p = 0.9); however, it was positively correlated with the number of granulomatous structures (r = 0.955). In conclusion, PTX does not affect development and collagen deposition in S. mansoni murine granuloma, but decreases the intragranulomatous eosinophil accumulation possibly due to its immunomodulatory capability, interfering in cellular recruitment and/or differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:50:16