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Titolo:
Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers as macromolecular MR contrast agents
Autore:
Kobayashi, H; Kawamoto, S; Saga, T; Sato, N; Hiraga, A; Ishimori, T; Konishi, J; Togashi, K; Brechbiel, MW;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Diagnost & Intervent Imagiol, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 t Imagiol, Sakyo Ku, Kyoto 6068507, Japan Dept Nucl Med & Diagnost Imaging, Kyoto, Japan Dept Nucl Med & Diagnost Imaging Kyoto Japan nost Imaging, Kyoto, Japan Kyoto Univ, Dept Radiol, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Dept Radiol, Kyoto, Japan Otsu Municipal Hosp, Dept Radiol, Otsu, Shiga, Japan Otsu Municipal Hosp Otsu Shiga Japan sp, Dept Radiol, Otsu, Shiga, Japan NCI, Radioimmune & Inorgan Chem Sect, Radiat Oncol Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 adiat Oncol Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 4, volume: 46, anno: 2001,
pagine: 781 - 788
SICI:
0740-3194(200110)46:4<781:PEOPGC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DTPA-LABELED DEXTRAN; GD-DTPA; MOLECULAR-WEIGHT; MONOCLONAL-ANTIBODY; ENHANCING AGENT; IMMUNOGENICITY; ANGIOGRAPHY; PHARMACOKINETICS; BIODISTRIBUTION; FLEXIBILITY;
Keywords:
macromolecular; MRI; contrast agent; polyamidoamine dendrimer; polyethylene glycol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, H Kyoto Univ, Grad Sch Med, Dept Diagnost & Intervent Imagiol, Sakyo Ku, 54 Kawahara Cho, Kyoto 6068507, Japan Kyoto Univ 54 Kawahara Cho Kyoto Japan 6068507 068507, Japan
Citazione:
H. Kobayashi et al., "Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers as macromolecular MR contrast agents", MAGN RES M, 46(4), 2001, pp. 781-788

Abstract

Macromolecules conjugated with polyethylene glycol (PEG) acquire more hydrophilicity, resulting In a longer half-life in circulation and lower Immunogenicity. Two novel conjugates for MRI contrast agents were synthesized from a generation-4 polyamidoamine dendrimer (G4D), 2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetriaminepentaacetic acid (1B4M), and one or two PEG molecules with a molecular weight of 20000 Da (PEG(2)-G4D-(1B4M-Gd)(62) (MW: 96 kD), PEG(1)-G4D-(1B4M-Gd)(63) (MW: 77 kD)), Their pharmacokinetics, excretion, and properties as vascular MRI contrast agents were evaluated and compared with those of G4D-(1B4M-Gd)(64) (MW: 57 kD). PEG(2)-G4D-(1B4M-Gd)(62)remained in the blood significantly longer and accumulated significantly less in the liver and kidney than the other two preparations (P < 0.01). Although the blood clearance was slower, PEG(2)-G4D-(1B4M-Gd)(62) was excretedmore readily without renal retention than the other two preparations. In conclusion, the positive effects of PEG conjugation on a macromolecular MRI contrast agent were found to be prolonged retention in the circulation, Increased excretion, and decreased accumulation in the organs. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:42:13