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Titolo:
Neurodegeneration: a failure of neuroregeneration?
Autore:
Armstrong, RJE; Barker, RA;
Indirizzi:
Univ Cambridge, Cambridge Ctr Brain Repair, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY air, Cambridge CB2 2PY, England Univ Cambridge, Dept Neurol, Cambridge, England Univ Cambridge CambridgeEngland ridge, Dept Neurol, Cambridge, England
Titolo Testata:
LANCET
fascicolo: 9288, volume: 358, anno: 2001,
pagine: 1174 - 1176
SICI:
0140-6736(20011006)358:9288<1174:NAFON>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL STEM-CELLS; CENTRAL-NERVOUS-SYSTEM; DENTATE GYRUS; ADULT MICE; NEUROGENESIS; NEOCORTEX; PROLIFERATION; PATHOGENESIS; DEGENERATION; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Barker, RA Univ Cambridge, Cambridge Ctr Brain Repair, Forvie Site,Robinson Way, Cambridge CB2 2PY, England Univ Cambridge Forvie Site,Robinson Way Cambridge England CB2 2PY
Citazione:
R.J.E. Armstrong e R.A. Barker, "Neurodegeneration: a failure of neuroregeneration?", LANCET, 358(9288), 2001, pp. 1174-1176

Abstract

Evidence suggests that the brain, like many other tissues, Is In a state of dynamic equilibrium. It has an endogenous population of stem cells that proliferate in response to environmental and pharmacological manipulations and that can replace cells lost In some experimental lesions. However, the fact remains that neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases are characterised by continuous loss of neurons that are not replaced. In this hypothesis, we postulate that a primary deficit In neural stem-cell proliferation; migration, or differentiation, orboth, might contribute to net cell loss and neuronal circuit disruption Inthese disorders. Experimental validation of this hypothesis would not onlysubstantially advance understanding of the pathogenesis of these diseases,but could also have profound implications for future treatment of these Incurable disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:33:14