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Titolo:
Heterogeneous immunogenetic background in Japanese adults with myasthenia gravis
Autore:
Suzuki, S; Kuwana, M; Yasuoka, H; Tanaka, K; Fukuuchi, Y; Kawakami, Y;
Indirizzi:
Keio Univ, Sch Med, Inst Adv Med Res, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 Med Res, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ, Sch Med, Dept Neurol, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 Sch Med, Dept Neurol, Tokyo 1608582, Japan Keio Univ, Sch Med, Dept Internal Med, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 d, Dept Internal Med, Tokyo 1608582, Japan
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1-2, volume: 189, anno: 2001,
pagine: 59 - 64
SICI:
0022-510X(20010815)189:1-2<59:HIBIJA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE HETEROGENEITY; HLA; SUSCEPTIBILITY; RESTRICTION; THYMECTOMY; PROGRESS; HLA-DPB1; ANTIGENS; CHINESE; GENES;
Keywords:
HLA; myasthenia gravis; thymectomy; acetylcholine receptor; autoimmune disease; immunogenetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kuwana, M Keio Univ, Sch Med, Inst Adv Med Res, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 hinjuku Ku, Tokyo 1608582, Japan
Citazione:
S. Suzuki et al., "Heterogeneous immunogenetic background in Japanese adults with myasthenia gravis", J NEUR SCI, 189(1-2), 2001, pp. 59-64

Abstract

The aim of this study was to elucidate the roles of human leukocyte antigen (HLA) class II genes in disease susceptibility in Japanese adult patientswith myasthenia gravis (MG). A number of studies have shown that MG is correlated with DR3 in Caucasians. In Japanese, infantile MG is associated with DR9, but the HLA class II alleles associated with adult MG remains unclear. HLA-DRB1 and DQB1 alleles were determined by genotyping in 75 Japanese adult patients with MG and in 115 race-matched healthy adults. No statistically significant difference was observed in the overall prevalences of DRB1 and DQB1 alleles between MG patients and healthy controls, even when the patients and controls were stratified on the basis of their gender. MG patients with DQB1*0604 were younger and those with DQB1*0402 were older at disease onset than those without (P = 0.03 and 0.008, respectively). Concomitantautoimmune thyroid disease was associated with DRB1*0803 ( P = 0.0009, corrected P = 0.04). In addition, anti-acetylcholine receptor antibody levels were significantly higher in patients with DQB1*0604 than in those without ( P = 0.045). These findings indicate that immunogenetic backgrounds in Japanese adult MG patients are heterogeneous and are apparently different fromthose in Caucasian patients. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 19/09/20 alle ore 18:02:10