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Titolo:
Intralesional granulocyte-monocyte colony-stimulating factor followed by subcutaneous interleukin-2 in metastatic melanoma: a pilot study in elderly patients
Autore:
Ridolfi, L; Ridolfi, R; Ascari-Raccagni, A; Fabbri, M; Casadei, S; Gatti, A; Trevisan, G; Righini, MG;
Indirizzi:
AUSL, Dept Med Oncol, Forli, Italy AUSL Forli ItalyAUSL, Dept Med Oncol, Forli, Italy AUSL, Dept Dermatol, Forli, Italy AUSL Forli ItalyAUSL, Dept Dermatol, Forli, Italy Univ Trieste, Dermatol Clin, Trieste, Italy Univ Trieste Trieste ItalyUniv Trieste, Dermatol Clin, Trieste, Italy Univ Bologna, Inst Haematol & Oncol, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 matol & Oncol, I-40126 Bologna, Italy
Titolo Testata:
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 218 - 223
SICI:
0926-9959(200105)15:3<218:IGCFFB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-INFILTRATING LYMPHOCYTES; DENDRITIC CELLS; RECOMBINANT INTERLEUKIN-2; IMMUNE-RESPONSES; CANCER-PATIENTS; GROWTH-FACTOR; GM-CSF; CARCINOMA; ANTIGEN; EXPRESSION;
Keywords:
interleukin-2; intralesional granulocyte-monocyte colony-stimulating factor; melanoma; subcutaneous metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Ridolfi, L Morgagni Pierantoni Hosp, Dept Med Oncol, Viale Forlanini 34, I-47100 Forli, Italy Morgagni Pierantoni Hosp Viale Forlanini 34 Forli Italy I-47100
Citazione:
L. Ridolfi et al., "Intralesional granulocyte-monocyte colony-stimulating factor followed by subcutaneous interleukin-2 in metastatic melanoma: a pilot study in elderly patients", J EUR A D V, 15(3), 2001, pp. 218-223

Abstract

Aim and background Recent data in the literature indicate that antigen-presenting cells (APC) are inactive in tumour tissue because of local immunosuppression. Tumour-infiltrating lymphocyte (TIL) signal activation transducing mechanisms are also seriously impaired. Administration of granulocyte macrophage-colony stimulating factor (GM-CSF) may lead to APC recovery and interleukin (IL)-2 may restore local TIL activation. Moreover, IL-2 increasesthe systemic lymphocyte population, an event that seems to correlate with a better prognosis. Study design The present phase I-II study was carried out to examine whether intralesional injection of GM-CSF followed by subcutaneous IL-2 would induce a clinical response in advanced, pretreated elderly melanoma patients. Methods Sixteen patients over 60 years of age received intralesional. GM-CSF (150 ng per lesion on day 1), generally divided between the two largest cutaneous lesions, followed by perilesional subcutaneous IL-2 (3 000 000 IU) for 5 days (days 3 - 7 inclusive) every 3 weeks. Results Four clinical responses [two partial (PR) and two minimal (MR)] (25%), which also involved lesions that had not been directly treated, and nine cases of stable disease were observed. The response duration for PR and MR was 9, 4, 4 and 2.5 + months, respectively. Stable disease (56%) recorded in the nine patients was short-term (3 - 6 months). Three patients rapidly progressed after two, two and one therapy cycles, respectively. The patient who reached the best PR had a fairly high absolute lymphocyte count (1600-2400/mm(3)). The second one, who reached complete remission after subsequent locoregional chemotherapy and hyperthermia, however, had a low absolutelymphocyte count that had doubled by the end of treatment. Blood lymphocyte values in the other patients were too varied to allow any correlation with clinical response. Therapy was well tolerated and only mild fever was observed, with the exception of one patient who had grade 3 fever, with musclepain and arthralgia. Conclusions Considering the very low toxicity observed, this treatment might be indicated in elderly patients for whom systemic therapy is no longer a viable option. Improved scheduling and timing could result from further studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:01:37