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Titolo:
Reflections on sterol sidechain cleavage process catalyzed by cytochrome P450(scc)
Autore:
Lieberman, S; Lin, YY;
Indirizzi:
St Lukes Roosevelt Hosp, Inst Hlth Sci, Dept Obstet & Gynecol, New York, NY 10019 USA St Lukes Roosevelt Hosp New York NY USA 10019 col, New York, NY 10019 USA
Titolo Testata:
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
fascicolo: 1, volume: 78, anno: 2001,
pagine: 1 - 14
SICI:
0960-0760(200107)78:1<1:ROSSCP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIDE-CHAIN CLEAVAGE; SINGLET OXYGEN; ERGOSTEROL BIOSYNTHESIS; CHOLESTEROL; PREGNENOLONE; MECHANISM; CONVERSION; ENZYME; INTERMEDIATE; PEROXIDASE;
Keywords:
sterol sidechain; cytochrome p450(scc); catalyze;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Lieberman, S St Lukes Roosevelt Hosp, Inst Hlth Sci, Dept Obstet & Gynecol, 432W 58th St, New York, NY 10019 USA St Lukes Roosevelt Hosp 432W 58th StNew York NY USA 10019 SA
Citazione:
S. Lieberman e Y.Y. Lin, "Reflections on sterol sidechain cleavage process catalyzed by cytochrome P450(scc)", J STEROID B, 78(1), 2001, pp. 1-14

Abstract

The essay examines the evidence upon which the presently accepted version of the mechanism of the cytochrome P450(scc)-catalyzed-cleavage of the sidechain of cholesterol is based. This analysis indicates that the generally held view of the process (two consecutive hydroxylations, followed by cleavage of the resulting glycol) most likely does not describe the true mechanism. The available evidence can not be used to support this traditional notion. Two alternative hypotheses are proposed. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:14:23