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Titolo:
Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism
Autore:
Gianoulakis, C;
Indirizzi:
Douglas Hosp, Res Ctr, Verdun, PQ H4H 1R3, Canada Douglas Hosp Verdun PQ Canada H4H 1R3 Res Ctr, Verdun, PQ H4H 1R3, Canada McGill Univ, Dept Psychiat, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Univ, Dept Psychiat, Montreal, PQ, Canada
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
fascicolo: 4, volume: 26, anno: 2001,
pagine: 304 - 318
SICI:
1180-4882(200109)26:4<304:IOTEOS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ENDORPHIN SYSTEM; AVOIDING ANA RATS; ETHANOL WITHDRAWAL SEIZURES; PITUITARY-ADRENAL AXIS; RECEPTOR MESSENGER-RNA; DISTINCT BRAIN-REGIONS; NUCLEUS-ACCUMBENS; PREFERRING AA; DBA/2 MICE; OPIATE RECEPTOR;
Keywords:
alcoholism; dopamine; endorphins; enkephalins; ethanol; dynorphins; genetic predisposition to disease; genetics; opioid peptides, receptors; opioid; reward;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
158
Recensione:
Indirizzi per estratti:
Indirizzo: Gianoulakis, C Douglas Hosp, Res Ctr, 6875 LaSalle Blvd, Verdun, PQ H4H 1R3, Canada Douglas Hosp 6875 LaSalle Blvd Verdun PQ Canada H4H 1R3 ada
Citazione:
C. Gianoulakis, "Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism", J PSYCH NEU, 26(4), 2001, pp. 304-318

Abstract

There is increasing evidence supporting a link between the endogenous opioid system and excessive alcohol consumption. Acute or light alcohol consumption stimulates the release of opioid peptides in brain regions that are associated with reward and reinforcement and that mediate, at least in part, the reinforcing effects of ethanol. However, chronic heavy alcohol, consumption induces a central opioid deficiency, which may be perceived as opioid Withdrawal and may promote alcohol consumption through the mechanisms of negative reinforcement. The role of genetic factors in alcohol dependency is well recognized, and there is evidence that the activity of the endogenous opioid system under basal conditions and in response to ethanol may play a role in determining an individual's predisposition to alcoholism. The effectiveness of opioid receptor antagonists in decreasing alcohol consumption in people with an alcohol dependency and in animal models lends further support to the view that the opioid system may regulate, either directly or through interactions with other neurotransmitters, alcohol. consumption. A better understanding of the complex interactions between ethanol, the endogenous opioids and. other neurotransmitter systems will help to delineate the neurochemical mechanisms leading to alcoholism and may lead to the development of novel treatments.

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Documento generato il 21/01/20 alle ore 07:24:56