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Titolo:
Labelled alpha-methyl-L-tryptophan as a tracer for the study of the brain serotonergic system
Autore:
Diksic, M;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Inst, Montreal, PQ H3A 2B4, Canada McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
fascicolo: 4, volume: 26, anno: 2001,
pagine: 293 - 303
SICI:
1180-4882(200109)26:4<293:LAAATF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; KYNURENINE PATHWAY METABOLISM; RAT-BRAIN; IN-VIVO; MONOAMINE-OXIDASE; 5-HYDROXYINDOLEACETIC ACID; AUTORADIOGRAPHIC METHOD; HYDROXYLASE ACTIVITY; CEREBROSPINAL-FLUID; HEALTHY-VOLUNTEERS;
Keywords:
brain; models, biological; radioactive tracers; serotonin; serotonin uptake inhibitors; tomography, emission-computed; tryptophan; tryptophan hydroxylase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Diksic, M McGill Univ, Montreal Neurol Inst, 3801 Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQ Canada H3A 2B4 2B4, Canada
Citazione:
M. Diksic, "Labelled alpha-methyl-L-tryptophan as a tracer for the study of the brain serotonergic system", J PSYCH NEU, 26(4), 2001, pp. 293-303

Abstract

The alpha -methyl-L-tryptophan (alpha -MTrp) method for the study of the brain serotonergic system is based on the fact that labelled alpha -MTrp is taken up by and, in part, retained in the brain, and this retention (trapping) is proportional to brain serotonin (5-HT) synthesis. A 3-compartment model is proposed in which the plasma, the precursor and irreversible pools are mathematically distinct compartments. The irreversible compartment is assumed to be the one in which the tracer is trapped. By definition, the tracer from the irreversible compartment does not exchange directly with the plasma compartment. The rate at which labelled alpha -MTrp is trapped is converted to the rate of 5-HT synthesis by dividing it by a conversion factor called the lumped constant, and multiplying it by the plasma-free tryptophanconcentration. Our results revealed that brain 5-HT synthesis can be influenced by the extraneuronal concentration of 5-HT and that, generally, the influence is not uniform throughout the brain. They also suggest that brain trapping of labelled alpha -MTrp relates to 5-HT synthesis. The proposed procedure for converting the rate at which labelled alpha -MTrp is trapped tobrain 5-HT synthesis rates is based on measurements that suggest that plasma-free Trp relates to brain 5-HT synthesis. However, as with all biological models, there is likely room for improvement in our approach.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 02:41:44