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Titolo:
Obstetric complications and Apgar score in early-onset schizophrenic patients with prominent positive and prominent negative symptoms
Autore:
Kotlicka-Antczak, M; Gmitrowicz, A; Sobow, TM; Rabe-Jablonska, J;
Indirizzi:
Med Univ Lodz, Dept Psychiat, PL-92216 Lodz, Poland Med Univ Lodz Lodz Poland PL-92216 Dept Psychiat, PL-92216 Lodz, Poland
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 4, volume: 35, anno: 2001,
pagine: 249 - 257
SICI:
0022-3956(200107/08)35:4<249:OCAASI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIRTH COHORT; RISK-FACTORS; NEURODEVELOPMENTAL SCHIZOPHRENIA; METAANALYSIS; PREGNANCY; DELIVERY; RECORDS; LABOR;
Keywords:
obstetric complications; Apgar score; schizophrenia; positive symptoms; negative symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kotlicka-Antczak, M Med Univ Lodz, Dept Psychiat, Czechoslowacka St 8-10, PL-92216 Lodz, Poland Med Univ Lodz Czechoslowacka St 8-10 Lodz Poland PL-92216
Citazione:
M. Kotlicka-Antczak et al., "Obstetric complications and Apgar score in early-onset schizophrenic patients with prominent positive and prominent negative symptoms", J PSYCH RES, 35(4), 2001, pp. 249-257

Abstract

The objective of the study was to find associations between obstetric complications (OCs) history and schizophrenia course and symptoms. We analysed the obstetric and psychiatric history of 50 DSM IV schizophrenic subjects who experienced their first schizophrenia episode in adolescence, and 30 healthy controls. Obstetrical data and Apgar scores were obtained from medicalrecords and evaluated with the Lewis and Murray Scale. Based on patients' documentation [including longitudinal evaluation with Positive and NegativeSyndrome Scale (PANSS)] the symptom profile and the course of schizophrenia were determined. Results: we distinguished two major groups of patients: with prominent negative and prominent positive symptoms. Schizophrenics with prominent negative symptoms and a chronic schizophrenia course had significantly more definite OCs and lower Apgar scores than patients with prominent positive symptoms and controls. Subjects who had a positive OCs history were more than four times likely to develop schizophrenia in adolescence than those without such a history (OR 4.64; 95% CI = 1.29-17.51) with the likelihood of developing schizophrenia with prominent negative symptoms especially high (OR = 7.31; 95% CI = 1.80-29.65). An Apgar score of between 0 and3 after birth was associated with an increased risk for developing schizophrenia (OR = 2.25; 95% CI = 0.56-9.12), especially with prominent negative symptoms (OR= 3.71; 95% Cl = 0.84-16.32). The findings support the hypothesis of a role of OCs in developing early-onset schizophrenia and suggest theassociations of the OCs history with a specific symptoms profile (prominent negative symptoms) and a chronic course of schizophrenia. (C) 2001 Elsevier Science Ltd. All rights reserved.

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Documento generato il 19/01/20 alle ore 20:43:01