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Titolo:
Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders
Autore:
Cusin, C; Serretti, A; Lattuada, E; Lilli, R; Lorenzi, C; Mandelli, L; Pisati, E; Smeraldi, E;
Indirizzi:
Vita Salute Univ, Ist Sci H San Raffaele, Dept Psychiat, I-20127 Milan, Italy Vita Salute Univ Milan Italy I-20127 Dept Psychiat, I-20127 Milan, Italy
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 4, volume: 35, anno: 2001,
pagine: 217 - 223
SICI:
0022-3956(200107/08)35:4<217:IO5ATV>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; MAJOR DEPRESSIVE DISORDER; PROSPECTIVE FOLLOW-UP; COLLABORATIVE RESEARCH-PROGRAM; FUNCTIONAL POLYMORPHISM; UNIPOLAR DEPRESSION; BIPOLAR DISORDER; CASE REGISTER; PROMOTER; RECOVERY;
Keywords:
bipolar disorder; follow-up studies; depressive disorder; rapid cycling; genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Serretti, A Vita Salute Univ, Ist Sci H San Raffaele, Dept Psychiat, Via Stamira Ancona 20, I-20127 Milan, Italy Vita Salute Univ Via Stamira Ancona 20 Milan Italy I-20127 ly
Citazione:
C. Cusin et al., "Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders", J PSYCH RES, 35(4), 2001, pp. 217-223

Abstract

The aim of our study was to investigate gene variants in the long-term outcome of mood disorders. We retrospectively studied a sample of inpatients affected by recurrent and rapid cycling mood disorders. The serotonin transporter gene-linked functional polymorphic region (5-HTTLPR) and the A218C tryptophan hydroxylase (TPH) gene variant were determined using a PCR-based technique. For 5-HTTLPR polymorphism we genotyped 435 inpatients affected bymajor depressive (n = 153), bipolar (n = 213) and rapid cycling (n = 69) mood disorders and 456 controls; for TPH we genotyped 399 inpatients (MD, n = 132; BP, n = 203; rapid cycling n = 64) and 259 controls. Random Regression Model analysis was used to investigate the longitudinal time course of the illness. 5-HTTLPR and TPH polymorphisms were not associated with mood disorders time course. However we observed an excess of 5-HTTLPR*long allelesamong rapid cycling subjects compared to both controls (P = 0.018) and remitting mood disorders (P = 0.006). TPH frequencies did not differ between mood disorders subtypes. Our results suggest that 5-HTTLPR variants may confer a susceptibility toward rapid cycling mood disorders. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:05:22