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Titolo:
Transcranial magnetic stimulation as a therapeutic tool in psychiatry: what do we know about the neurobiological mechanisms?
Autore:
Post, A; Keck, ME;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 4, volume: 35, anno: 2001,
pagine: 193 - 215
SICI:
0022-3956(200107/08)35:4<193:TMSAAT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; AMYLOID PRECURSOR PROTEIN; ANXIETY-RELATED BEHAVIOR; NF-KAPPA-B; CHRONIC ELECTROCONVULSIVE SHOCK; MEDIAL PREFRONTAL CORTEX; FORCED SWIMMING TEST; GLUTAMATE-INDUCED NEUROTOXICITY; NEUROTROPHIC FACTOR BDNF; MOTOR-EVOKED-POTENTIALS;
Keywords:
repetitive transcranial magnetic stimulation; stress; depression; antidepressant; HPA system; ACTH; BDNF; dopamine; neuroprotection; vasopressin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
194
Recensione:
Indirizzi per estratti:
Indirizzo: Keck, ME Max Planck Inst Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 2-10 Munich Germany D-80804
Citazione:
A. Post e M.E. Keck, "Transcranial magnetic stimulation as a therapeutic tool in psychiatry: what do we know about the neurobiological mechanisms?", J PSYCH RES, 35(4), 2001, pp. 193-215

Abstract

Potential therapeutic properties of repetitive transcranial magnetic stimulation (rTMS) have been suggested in several psychiatric disorders such as depression. mania, obsessive-compulsive disorder, posttraumatic stress disorder and schizophrenia. By inducing electric currents in brain tissue via atime-varying strong magnetic field, rTMS has the potential to either directly or trans-synaptically modulate neuronal circuits thought to be dysfunctional in these psychiatric disorders. However, in order to optimize rTMS for therapeutic use, it is necessary to understand the neurobiological mechanisms involved, particularly the nature of the changes induced and the brainregions affected. Compared to the growing number of clinical studies on its putative therapeutic properties, the studies on the basic mechanisms of rTMS are surprisingly scarce. rTMS currently still awaits clinical routine administration although,there is compelling evidence that it causes changes in neuronal circuits as reflected by behavioural changes and decreases in the activity of the hypothalamic-pituitary-adrenocortical system. Both alterations suggest regional changes in neurotransmitter/ neuromodulator release, transsynaptic efficiency, signaling pathways and in gene transcription. Together, these changes are, in part. reminiscent of those accompanying antidepressant drugs. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:20:36