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Titolo:
The involvement of GABA(A) receptors in the control of gnrh and beta-endorphin release, and catecholaminergic activity in the ventromedial-infundibular region of hypothalamus in anestrous ewes
Autore:
Tomaszewska-Zaremba, D; Przekop, F; Mateusiak, K;
Indirizzi:
Polish Acad Sci, Kielanowski Inst Anim Physiol & Nutr, PL-05110 Jablonna, Poland Polish Acad Sci Jablonna Poland PL-05110 Nutr, PL-05110 Jablonna, Poland
Titolo Testata:
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
fascicolo: 3, volume: 52, anno: 2001,
pagine: 489 - 500
SICI:
0867-5910(200109)52:3<489:TIOGRI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREOPTIC AREA; LUTEINIZING-HORMONE SECRETION; NOREPINEPHRINE RELEASE; DOPAMINERGIC-NEURONS; GABAERGIC REGULATION; GENE-EXPRESSION; LHRH NEURONS; FEMALE RATS; ACID; NORADRENALINE;
Keywords:
ewe; hypothalamus; gonadotropin-releasing hormone (GnRH); beta-endorphin (B-END); gamma-aminobutyric acid (GABA); catecholamines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Tomaszewska-Zaremba, D Polish Acad Sci, Kielanowski Inst Anim Physiol & Nutr, PL-05110 Jablonna, Poland Polish Acad Sci Jablonna Poland PL-05110 , Poland
Citazione:
D. Tomaszewska-Zaremba et al., "The involvement of GABA(A) receptors in the control of gnrh and beta-endorphin release, and catecholaminergic activity in the ventromedial-infundibular region of hypothalamus in anestrous ewes", J PHYSL PH, 52(3), 2001, pp. 489-500

Abstract

To examine the role of the GABA(A) receptor mediating systems in the control of gonadotropin-releasing hormone (GnRH) release from the ventromedial-infundibular region (VEN/IN) of anestrous ewes, the extracellular concentrations of GnRH, beta -endorphin, noradrenaline (NE), dopamine (DA), 4-hydroxy-3-methoxy-phenyl-glycol (MHPG) and 3,4-dihydroxy-phenylacetic acid (DOPAC)were quantified during local stimulation or blockade of GABA(A) receptors with muscimol or bicuculline respectively. In most animals stimulation of GABA, receptors significantly attenuates GnRH release with concomitant increase of P-endorphin and DA release, and MHPG and DOPAC levels. Blockade of the GABA(A) receptors generally did not affect GnRH and NE release but inhibited in most animals P-endorphin release and decreased dopaminergic activity. These results suggest, that GABA may suppress GnRH release directly by GABA, receptor mechanism on the axon terminal of GnRH neurons or indirectly by GABA(A) receptor processes activating beta -endorphin-ergic and dopaminergic neurons in the VEN/NI. On the basis of these results in could not be distinguish between these two events. The decrease in extracellular beta -endorphin and dopamine concentration without evident changes in the GnRH level during GABA(A) receptor blockade may suggest that other neuronal systems are involved in this effect.

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Documento generato il 04/12/20 alle ore 12:22:44