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Titolo:
Unveiling the functions of presynaptic metabotropic glutamate receptors inthe central nervous system
Autore:
Schoepp, DD;
Indirizzi:
Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Neurosci Res Ctr, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis IN USA 46285 Ctr, Indianapolis, IN 46285 USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 1, volume: 299, anno: 2001,
pagine: 12 - 20
SICI:
0022-3565(200110)299:1<12:UTFOPM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROUP-II; MICE LACKING; GABA(B) RECEPTOR; MGLUR4 SUBTYPE; PERFORANT PATH; BASAL GANGLIA; MESSENGER-RNA; RAT-BRAIN; LOCALIZATION; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Schoepp, DD Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Neurosci Res Ctr, Drop 0510, Indianapolis, IN 46285 USA Eli Lilly & Co Drop 0510 Indianapolis IN USA 46285 N 46285 USA
Citazione:
D.D. Schoepp, "Unveiling the functions of presynaptic metabotropic glutamate receptors inthe central nervous system", J PHARM EXP, 299(1), 2001, pp. 12-20

Abstract

Metabotropic glutamate (mGlu) receptors, which include mGlu1-8 receptors, are a heterogeneous family of G-protein-coupled receptors which function tomodulate brain excitability via presynaptic, postsynaptic and glial mechanisms. Certain members of this receptor family have been shown to function as presynaptic regulatory mechanisms to control release of neurotransmitters. In general, Gi-coupled mGlu receptor subtypes appear to negatively modulate excitatory (and possibly also inhibitory) neurotransmitter output when activated. Localization studies have shown that mGlu7 is restricted to the presynaptic grid at the site of vesicle fusion. These studies along with other evidence suggest that mGlu7 is the nerve terminal autoreceptor that regulates physiological release of glutamate. Other mGlu subtypes, in particular mGlu2, mGlu8, and possibly mGlu4, are also localized presynaptically, butat perisynaptic sites outside the active zone of neurotransmitter release. Gi-coupled mGlu receptors also may exist on presynaptic elements of neighboring gamma -aminobutyric acid (GABA) neurons where they play a role in heterosynaptic suppressions of GABA release. This suggests that these receptors may have evolved to monitor glutamate that has "spilled" out of the synapse. Thus, they may serve as the brain's evolutionary mechanism to prevent pathological changes in neuronal excitability and thus maintain homeostasis. Recent progress on the molecular and pharmacological aspects of these presynaptic mGlu receptors is unveiling their functions and the therapeutic directions of agents designed for these novel glutamate receptor targets.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 06:18:21