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Titolo:
Beneficial effect of dietary wheat glycolipids on cecum short-chain fatty acid and secondary bile acid profiles in mice
Autore:
Sugawara, T; Miyazawa, T;
Indirizzi:
Tohoku Univ, Grad Sch Life Sci & Agr, Chem Biodynam Lab, Sendai, Miyagi 9818555, Japan Tohoku Univ Sendai Miyagi Japan 9818555 ab, Sendai, Miyagi 9818555, Japan
Titolo Testata:
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
fascicolo: 4, volume: 47, anno: 2001,
pagine: 299 - 305
SICI:
0301-4800(200108)47:4<299:BEODWG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER CELL-LINES; LARGE-BOWEL CANCER; COLON-CANCER; LIQUID-CHROMATOGRAPHY; BUTYRATE PRODUCTION; SODIUM-BUTYRATE; RATS; FIBER; METABOLISM; DIGALACTOSYLDIACYLGLYCEROL;
Keywords:
cecum; glycolipids; mice; secondary bile acids; short-chain fatty acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Miyazawa, T Tohoku Univ, Grad Sch Life Sci & Agr, Chem Biodynam Lab, Sendai, Miyagi 9818555, Japan Tohoku Univ Sendai Miyagi Japan 9818555 Miyagi 9818555, Japan
Citazione:
T. Sugawara e T. Miyazawa, "Beneficial effect of dietary wheat glycolipids on cecum short-chain fatty acid and secondary bile acid profiles in mice", J NUTR SC V, 47(4), 2001, pp. 299-305

Abstract

In the present study, to explore the beneficial effect of dietary galactoglycerolipids on the lower digestive tract environment, male BALB/c mice were fed a 5% wheat glycolipid, fiber-free diet, or the standard AIN diet for 3 wk. The wheat glycolipid composition was digalactosyldiacylglycerol 51.6%, ceramide monohexoside 6.6%, acylated sterylglucoside 3.4%, and other lipids 22.2% (mostly phospholipids). Cecum and colon weights and colonic crypt depth were significantly greater in the glycolipid-diet mice relative to groups fed the other two diets. Furthermore, in the cecum, propionate, butyrate, and total short-chain fatty acids, concentrations were significantly greater in the glycolipid-diet mice than others were, and correlated with theobserved increased lower digestive tract (cecum and colon) weights and colonic crypt depth. The cecal lithocholic acid/deoxycholic acid ratio, a riskindex for colorectal cancer. was significantly lower in the glycolipid-diet mice than in the other two dietary groups. These results suggest that thedietary supplementation of plant-source galactoglycerolipids may contribute to improving the lower digestive tract environment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:45:38