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Titolo:
Influence of dietary protein levels on beta-alanine aminotransferase expression and activity in rats
Autore:
Ito, S; Ohyama, T; Kontani, Y; Matsuda, K; Sakata, SF; Tamaki, N;
Indirizzi:
Kobe Gakuin Univ, Fac Nutr, Nutr Chem Lab, Kobe, Hyogo 6512180, Japan KobeGakuin Univ Kobe Hyogo Japan 6512180 Lab, Kobe, Hyogo 6512180, Japan Kobe Gakuin Univ, High Technol Res Ctr, Kobe, Hyogo 6512180, Japan Kobe Gakuin Univ Kobe Hyogo Japan 6512180 Ctr, Kobe, Hyogo 6512180, Japan
Titolo Testata:
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
fascicolo: 4, volume: 47, anno: 2001,
pagine: 275 - 282
SICI:
0301-4800(200108)47:4<275:IODPLO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-3-AMINOISOBUTYRATE AMINOTRANSFERASE; 4-AMINOBUTYRATE AMINOTRANSFERASE; LIVER; PURIFICATION; BRAIN; IDENTITY; DEHYDROGENASE; DEFICIENCY; INHIBITION; ENZYMES;
Keywords:
aminobutyrate aminotransferase; B-alanine-pyruvate aminotransferase; low-protein diet; high-protein diet;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Tamaki, N Kobe Gakuin Univ, Fac Nutr, Nutr Chem Lab, Kobe, Hyogo 6512180, Japan Kobe Gakuin Univ Kobe Hyogo Japan 6512180 Hyogo 6512180, Japan
Citazione:
S. Ito et al., "Influence of dietary protein levels on beta-alanine aminotransferase expression and activity in rats", J NUTR SC V, 47(4), 2001, pp. 275-282

Abstract

beta -Alanine-oxoglutarate aminotransferase (beta -AlaAT I) and beta -alanine-pyruvate aminotransferase (beta -AlaAT II) catalyze the transamination reaction of omega -amino acids such as beta -alanine. beta -aminoisobutyrate, and gamma -aminobutyrate, amino acids that are not protein constituents. The influence of dietary protein levels on the expression and activities of these enzymes was investigated by using male rats. Both beta -AlaAT I andbeta -AlaAT II activities in the liver were increased with the level of protein in the diet in accordance with changes in their mRNA levels. However,the beta -AlaAT I activity in the kidney was increased by protein-free andlow-protein diets in relation to changes in its mRNA level. On the other hand, the level of beta -AlaAT II activity in the kidney was slightly decreased by a protein-free diet. Neither beta -AlaAT I nor beta -AlaAT II activities in the kidney were affected by a high-protein diet. These results suggested that beta -alanine may be used efficiently in animals fed a protein-free or low-protein diet because the kidney provides beta -alanine by means of the hydrolysis of beta -alanyl-L-histidine (carnosine). The addition of beta -alanine to the diet significantly activated beta -AlaAT I in the kidneys of rats in accordance with changes in its mRNA level. In the rat brain,beta -AlaAT I activity was not altered by the dietary protein level or by the beta -alanine diet, and beta -AlaAT II activity was not detected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 21:51:07