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Titolo:
Differential regulation of p75 and trkB mRNA expression after depolarizingstimuli or BDNF treatment in basal forebrain neuron cultures
Autore:
Elliott, RC; Black, IB; Dreyfus, CF;
Indirizzi:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey Piscataway NJ USA 08854 scataway, NJ 08854 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 1, volume: 66, anno: 2001,
pagine: 83 - 88
SICI:
0360-4012(20011001)66:1<83:DROPAT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; SEPTAL CHOLINERGIC NEURONS; FIMBRIA-FORNIX TRANSECTION; TYROSINE KINASE RECEPTOR; MESSENGER-RNA EXPRESSION; NEUROTROPHIC FACTOR; GENE-EXPRESSION; SYNAPTIC TRANSMISSION; SENSORY NEURONS; RAT HIPPOCAMPUS;
Keywords:
neurotrophin; receptor; hippocampus; plasticity; activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Elliott, RC Harvard Univ, Inst Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Rm 858,77 Ave Louis Pasteur, Boston, MA 02215 USA Harvard Univ Rm 858,77 Ave Louis Pasteur Boston MA USA 02215 A
Citazione:
R.C. Elliott et al., "Differential regulation of p75 and trkB mRNA expression after depolarizingstimuli or BDNF treatment in basal forebrain neuron cultures", J NEUROSC R, 66(1), 2001, pp. 83-88

Abstract

Extensive evidence suggests that BDNF regulates neural function and architecture after depolarization. Expression of BDNF is increased after depolarization, and the ability of BDNF to modulate synaptic function is well documented. To further investigate BDNF signaling after activity, we analyzed the effects of depolarization or BDNF treatment on receptor mRNA expression in cultured basal forebrain neurons. Levels of mRNA coding for the cognate BDNF receptor, trkB, as well as the common neurotrophin receptor, p75, were quantitated simultaneously using a sensitive solution hybridization technique. Depolarization or BDNF treatment increased p75 mRNA expression 94% and 195%, respectively. In contrast, trkB message decreased 23% after depolarization but was unchanged by BDNF treatment. Together, these changes resultedin significant increases in the p75/trkB ratio after depolarization or BDNF treatment that could alter BDNF binding or signal transduction. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 23/01/20 alle ore 18:20:29