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Titolo:
Cannabinoid receptor agonist WIN 55,212-2 inhibits rat cortical dialysate gamma-aminobutyric acid levels
Autore:
Ferraro, L; Tomasini, MC; Cassano, T; Bebe, BW; Siniscalchi, A; OConnor, WT; Magee, P; Tanganelli, S; Cuomo, V; Antonelli, T;
Indirizzi:
Univ Ferrara, Dept Clin & Expt Med, Pharmacol Sect, I-44100 Ferrara, ItalyUniv Ferrara Ferrara Italy I-44100 harmacol Sect, I-44100 Ferrara, Italy Univ Bari, Dept Pharmacol & Human Physiol, Bari, Italy Univ Bari Bari Italy Bari, Dept Pharmacol & Human Physiol, Bari, Italy Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Human Anat & Physiol, Dublin 2, Ireland Univ Coll Dublin Dublin Ireland 2 uman Anat & Physiol, Dublin 2, Ireland
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 2, volume: 66, anno: 2001,
pagine: 298 - 302
SICI:
0360-4012(20011015)66:2<298:CRAW5I>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL-PREFRONTAL CORTEX; WORKING-MEMORY; ACETYLCHOLINE-RELEASE; SYNAPTIC TRANSMISSION; CB1 RECEPTORS; BRAIN; HIPPOCAMPUS; NEURONS; INTERNEURONS; IMPAIRMENT;
Keywords:
cannabinoid receptor agonist and antagonist; intraperitoneal injection; microdialysis; marijuana;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ferraro, L Univ Ferrara, Dept Clin & Expt Med, Pharmacol Sect, Via FossatoMortara 17-19, I-44100 Ferrara, Italy Univ Ferrara Via Fossato Mortara 17-19 Ferrara Italy I-44100 y
Citazione:
L. Ferraro et al., "Cannabinoid receptor agonist WIN 55,212-2 inhibits rat cortical dialysate gamma-aminobutyric acid levels", J NEUROSC R, 66(2), 2001, pp. 298-302

Abstract

The effects of the cannabinoid receptor agonist WIN 55,212-2 (0.1-5 mg/kg i.p.) on endogenous extracellular gamma -aminobutyric acid (GABA) levels inthe cerebral cortex of the awake rat was investigated by using microdialysis. WIN 55,212-2 (1 and 5 mg/kg i.p.) was associated with a concentration-dependent decrease in dialysate GABA levels (-16% +/- 4% and -26% +/- 4% of basal values, respectively). The WIN 55,212-2 (5 mg/kg i.p.) induced-inhibition was counteracted by a dose (0.1 mg/kg i.p.) of the CB, receptor antagonist SR141716A, which by itself was without effect on cortical GABA levels. These findings suggest that cannabinoids decrease cortical GABA levels in vivo, an action that might underlie some of the cognitive and behavioral effects of acute exposure to marijuana. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:29:48