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Titolo:
Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats
Autore:
Ando, S; Tadenuma, T; Tanaka, Y; Fukui, F; Kobayashi, S; Ohashi, Y; Kawabata, T;
Indirizzi:
Tokyo Metropolitan Inst Gerontol, Dept Membrane Biochem, Itabashi Ku, Tokyo 1730015, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan 1730015 okyo 1730015, Japan Tokyo Metropolitan Inst Gerontol, Dept Cell Recognit, Itabashi Ku, Tokyo 1730015, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan 1730015 okyo 1730015, Japan Shukutoku Univ, Fac Sociol, Chuo Ku, Chiba, Japan Shukutoku Univ Chiba Japan toku Univ, Fac Sociol, Chuo Ku, Chiba, Japan Kagawa Univ, Fac Nutr, Sakado, Saitama, Japan Kagawa Univ Sakado Saitama Japan Univ, Fac Nutr, Sakado, Saitama, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 2, volume: 66, anno: 2001,
pagine: 266 - 271
SICI:
0360-4012(20011015)66:2<266:EOLCAC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYL-L-CARNITINE; AGE-RELATED-CHANGES; ACETYLCHOLINE-RELEASE; ALZHEIMERS-DISEASE; SPATIAL MEMORY; BASAL FOREBRAIN; CORTICAL SYNAPTOSOMES; MAZE PERFORMANCE; WORKING-MEMORY; RADIAL MAZE;
Keywords:
carnitine; acetylcholine synthesis; learning; aging rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Ando, S Tokyo Metropolitan Inst Gerontol, Dept Membrane Biochem, Itabashi Ku, 35-2Sakaecho, Tokyo 1730015, Japan Tokyo Metropolitan Inst Gerontol 35-2 Sakaecho Tokyo Japan 1730015
Citazione:
S. Ando et al., "Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats", J NEUROSC R, 66(2), 2001, pp. 266-271

Abstract

The effects of a carnitine derivative, acetyl-L-carnitine (ALCAR), on the cognitive and cholinergic activities of aging rats were examined. Rats weregiven ALCAR (100 mg/kg) per os for 3 months and were subjected to the Hebb-Williams tasks and a new maze task, AKON-1, to assess their learning capacity. The learning capacity of the ALCAR-treated group was superior to that of the control. Cholinergic activities were determined with synaptosomes isolated from the cortices. The high-affinity choline uptake by synaptosomes,acetylcholine synthesis in synaptosomes, and acetylcholine release from synaptosomes on membrane depolarization were all enhanced in the ALCAR group. This study indicates that chronic administration of ALCAR increases cholinergic synaptic transmission and consequently enhances learning capacity as a cognitive function in aging rats. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 08:41:53