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Titolo:
Altered circadian cortisol secretion in Alzheimer's disease: Clinical and neuroradiological aspects
Autore:
Giubilei, F; Patacchioli, FR; Antonini, G; Monti, MS; Tisei, P; Bastianello, S; Monnazzi, P; Angelucci, L;
Indirizzi:
Univ La Sapienza, Dipartimento Sci Neurol, I-00185 Rome, Italy Univ La Sapienza Rome Italy I-00185 ento Sci Neurol, I-00185 Rome, Italy Univ La Sapienza, Dipartimento Fisiol Umana & Farmacol, Rome, Italy Univ La Sapienza Rome Italy imento Fisiol Umana & Farmacol, Rome, Italy
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 2, volume: 66, anno: 2001,
pagine: 262 - 265
SICI:
0360-4012(20011015)66:2<262:ACCSIA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; SALIVARY CORTISOL; DEXAMETHASONE SUPPRESSION; COMPUTED-TOMOGRAPHY; SENILE DEMENTIA; PROGRESSION; ASSOCIATION; MODULATION; CYTOKINES; HORMONE;
Keywords:
Alzheimer's disease; cortisol; neuroimaging; cognitive impairment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Giubilei, F Univ La Sapienza, Dipartimento Sci Neurol, Viale Univ 30, I-00185 Rome, Italy Univ La Sapienza Viale Univ 30 Rome Italy I-00185 Rome, Italy
Citazione:
F. Giubilei et al., "Altered circadian cortisol secretion in Alzheimer's disease: Clinical and neuroradiological aspects", J NEUROSC R, 66(2), 2001, pp. 262-265

Abstract

We determined circadian salivary cortisol levels in 18 outpatients affected by probable Alzheimer's disease (AD) and looked for a possible correlation with both cognitive impairment and brain CT scan findings. The diagnosis of probable AD was made according to the NINCDS-ADRDA criteria. The severity of cognitive impairment was quantified using the Mini Mental State Examination (MMSE) and the Global Deterioration Scale (GDS). Cortisol levels weremeasured on saliva samples collected at 08:00 Am and 08:00 Pm. For each sample, a duplicate cortisol measurement was performed on 50 W of saliva by means of a modified commercial radioimmunoassay kit. At the same time, 11 ofthe 18 AD patients enrolled also underwent a brain CT scan to estimate cerebral atrophy by using linear indexes. The mean value of cortisol levels was significantly higher in AD patients than in controls at both the morning and the evening measurements, and the circadian fluctuation of cortisol wasless marked in AD patients than in controls, although this difference did not reach statistical significance. Morning cortisol levels were significantly correlated to both the MMSE and the GDS scores. A significant correlation was also found between morning cortisol levels and all the cerebral atrophy indexes. By contrast, no correlation was observed between evening cortisol levels or cortisol circadian fluctuations and either cognitive impairment or cerebral atrophy. In conclusion, despite the potential biases deriving from the small sample and the limitations of the CT scan study, our results suggest that, in AD patients, hypercortisolemia is correlated with severity of the disease. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:30:49