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Titolo:
Functional neuroanatomy of the ventral striopallidal GABA pathway - New sites of intervention in the treatment of schizophrenia
Autore:
OConnor, WT;
Indirizzi:
Univ Coll Dublin, Dept Human Anat & Physiol, Conway Inst Biomed & Biomol Res, Dublin 2, Ireland Univ Coll Dublin Dublin Ireland 2 Biomed & Biomol Res, Dublin 2, Ireland
Titolo Testata:
JOURNAL OF NEUROSCIENCE METHODS
fascicolo: 1, volume: 109, anno: 2001,
pagine: 31 - 39
SICI:
0165-0270(20010815)109:1<31:FNOTVS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; ADENOSINE-DOPAMINE INTERACTIONS; DUAL-PROBE MICRODIALYSIS; RAT NUCLEUS-ACCUMBENS; IN-VIVO MICRODIALYSIS; NEUROTENSIN RECEPTORS; INVIVO MICRODIALYSIS; STRIATAL DOPAMINE; BASAL GANGLIA; B RECEPTOR;
Keywords:
SKF28293; pergolide; SCH23390; raclopride; CCK; PD13430; neurotensin; posphodiepryl 08; SR48692;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: O'Connor, WT Univ Coll Dublin, Dept Human Anat & Physiol, Conway Inst Biomed & Biomol Res, Earlsfort Terrace, Dublin 2, Ireland Univ Coll Dublin Earlsfort Terrace Dublin Ireland 2 Ireland
Citazione:
W.T. O'Connor, "Functional neuroanatomy of the ventral striopallidal GABA pathway - New sites of intervention in the treatment of schizophrenia", J NEUROSC M, 109(1), 2001, pp. 31-39

Abstract

Microdialysis was employed to investigate the dopamine, cholecystokinin (CCK) and neurotensin receptor regulation of ventral striopallidal GABA transmission by intra-accumbens perfusion with selective receptor ligands and monitoring local or ipsilateral ventral pallidal GABA release. In the dual probe studies intra-accumbens perfusion with the dopamine D-1 and D-2 receptor agonists SKF28293 and pergolide had no effect on ventral pallidal GABA, while both the D-1 and D-2 receptor antagonists SCH23390 and raclopride increased ventral pallidal GABA release. In contrast, intra-accumbens CCK decreased ventral pallidal GABA release and this was reversed by local perfusionwith the CCK2 receptor antagonist PD134308 but not the CCK, receptor antagonist L-364,718. In a single probe study intra-accumbens neurotensin increased local GABA release, which was strongly potentiated when the peptidase inhibitor phosphodiepryl 08 was perfused together with neurotensin. In addition, the neurotensin receptor antagonist SR48692 counteracted this phosphodiepryl 08 induced potentiated increased in GA-BA release. Taken together, these findings indicate that mesolimbic dopamine and CCK exert a respective tonic and phasic inhibition of ventral pallidal GABA release while the antipsychotic activity associated with D-1 and D-2 receptor antagonists may be explained by their ability to increase ventral striopallidal GABA transmission. Furthermore, the findings suggest that CCK2 receptor antagonists and neurotensin endopeptidase inhibitors may be useful antipsychotics. (C) 2001 Published by Elsevier Science B.V.

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Documento generato il 18/01/20 alle ore 21:37:31