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Titolo:
Potentiation of opioid analgesia in dopamine(2) receptor knock-out mice: Evidence for a tonically active anti-opioid system
Autore:
King, MA; Bradshaw, S; Chang, AH; Pintar, JE; Pasternak, GW;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Lab Mol Neuropharmacol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Cell Biol & Neurosci, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey Piscataway NJ USA 08854 scataway, NJ 08854 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 19, volume: 21, anno: 2001,
pagine: 7788 - 7792
SICI:
0270-6474(20011001)21:19<7788:POOAID>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; ORPHANIN-FQ; NUCLEUS-ACCUMBENS; SIGMA(1) RECEPTOR; MESSENGER-RNA; D-2 RECEPTOR; SPINAL-CORD; MORPHINE; RAT; FQ/NOCICEPTIN;
Keywords:
analgesia; dopamine; dopamine receptor; D-2 receptor; knock-out; antisense; anti-opioid; nociception; analgesic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Pasternak, GW Mem Sloan Kettering Canc Ctr, Lab Mol Neuropharmacol, 1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr 1275 York Ave New York NY USA 10021
Citazione:
M.A. King et al., "Potentiation of opioid analgesia in dopamine(2) receptor knock-out mice: Evidence for a tonically active anti-opioid system", J NEUROSC, 21(19), 2001, pp. 7788-7792

Abstract

Dopamine systems are intimately involved with opioid actions. Pharmacological studies suggest an important modulatory effect of dopamine and Its receptors on opioid analgesia. We have now examined these interactions in a knock-out model in which the dopamine(2) (D-2), receptor has been disrupted. Loss of D-2 receptors, enhances, in a dose-dependent manner, the analgesic actions of the mu analgesic morphine, the kappa (1) agonist U50,488H and thekappa (3) analgesic naloxone, benzoylhydrazone. The responses to the deltaopioid analgesic [D-Pen(2),D-Pen(5)]enkephalin were unaffected in the knock-out animals. Loss of D-2 receptors also potentiated, spinal orphanin FQ/nociceptin analgesia. Antisense studies using a probe targeting the D-2 receptor revealed results similar to those observed in the knock-out model. Themodulatory actions of D-2 receptors were independent of a receptor systemsbecause the sigma agonist (+)-pentazocine lowered opioid analgesia in all mice, including the D-2 knock-out group. Thus, dopamine D-2 receptors represent an additional, significant modulatory system that inhibits analgesic responses to mu and kappa opioids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:41:25