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Titolo:
The role of the primate amygdala in conditioned reinforcement
Autore:
Parkinson, JA; Crofts, HS; McGuigan, M; Tomic, DL; Everitt, BJ; Roberts, AC;
Indirizzi:
Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England Univ Cambridge Cambridge England CB2 3DY nat, Cambridge CB2 3DY, England Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3DY, England Univ Cambridge Cambridge England CB2 3DY hol, Cambridge CB2 3DY, England
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 19, volume: 21, anno: 2001,
pagine: 7770 - 7780
SICI:
0270-6474(20011001)21:19<7770:TROTPA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY SECONDARY REINFORCEMENT; STIMULUS REWARD ASSOCIATIONS; EXCITOTOXIC LESIONS; BASOLATERAL AMYGDALA; PREFRONTAL CORTEX; 2ND-ORDER SCHEDULE; COCAINE INJECTION; FOOD PRESENTATION; VENTRAL STRIATUM; RHESUS-MONKEYS;
Keywords:
appetitive conditioning; marmoset; excitotoxic; goal-directed behavior; incentive value; second-order schedule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Parkinson, JA Univ Cambridge, Dept Anat, Downing St, Cambridge CB2 3DY, England Univ Cambridge Downing St Cambridge England CB2 3DY England
Citazione:
J.A. Parkinson et al., "The role of the primate amygdala in conditioned reinforcement", J NEUROSC, 21(19), 2001, pp. 7770-7780

Abstract

Conditioned reinforcement refers, to the capacity of a conditioned stimulus, to support instrumental behavior by acquiring affective properties of the primary reinforcer with which it is associated. Conditioned reinforcers maintain behavior over protracted periods of time in the absence of, and potentially in conflict with, primary reinforcers and as, such may play a fundamental role in complex social behavior. A relatively large body of evidence supports, the view that the amygdala (and in particular the basolateral; area) contributes to conditioned reinforcement by maintaining a representation of the affective value of conditioned stimuli. However, a recent study in primates (Malkova et al., 1997), using a second-order visual discrimination task, suggests that the amygdala is not critical for the conditioned reinforcement process. In the present study, excitotoxic lesions, of the amygdala in a new world primate, the common marmoset, resulted in a progressive impairment in responding under a second-order schedule of food reinforcement. In addition, theresponding of amygdala-lesioned animals was insensitive to the omission ofthe conditioned reinforcer, unlike that of control animals, for which responding was markedly reduced. In contrast, lesioned animals were unimpaired when responding on a progression of fixed-ratio schedules of primary reinforcement. These data confirm that the amygdala is critical for the conditioned reinforcement process in primates, and taken together with other recent work in monkeys, these results suggest that the contribution of the amygdala is to provide the affective value of specific reinforcers as accessed by associated conditioned stimuli.

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Documento generato il 31/03/20 alle ore 04:46:49