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Titolo:
Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice
Autore:
Camarero, G; Avendano, C; Fernandez-Moreno, C; Villar, A; Contreras, J; de Pablo, F; Pichel, JG; Varela-Nieto, I;
Indirizzi:
Univ Autonoma Madrid, CSIC, Inst Invest Biomed Alberto Sols, E-28049 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28049 to Sols, E-28049 Madrid, Spain Univ Autonoma Madrid, Fac Med, Dept Morphol, E-28029 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28029 Morphol, E-28029 Madrid, Spain CSIC, Ctr Invest Biol, Dept Cell & Dev Biol, E-28006 Madrid, Spain CSIC Madrid Spain E-28006 l, Dept Cell & Dev Biol, E-28006 Madrid, Spain Univ Complutense Madrid, Fac Vet, Dept Anat, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 Anat, E-28040 Madrid, Spain
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 19, volume: 21, anno: 2001,
pagine: 7630 - 7641
SICI:
0270-6474(20011001)21:19<7630:DIEMAN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-I; CENTRAL-NERVOUS-SYSTEM; COCHLEAR HAIR-CELLS; IGF-I; TRANSGENIC MICE; STEREOLOGICAL METHODS; TECTORIAL MEMBRANE; SENSORY EPITHELIA; GENE-EXPRESSION; RAT COCHLEAR;
Keywords:
cochlear ganglion; insulin-like growth factor 1; IGF-1; myelination; neurogenesis; organ of Corti; synaptogenesis; stereology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Varela-Nieto, I Univ Autonoma Madrid, CSIC, Inst Invest Biomed Alberto Sols, Arturo Duperier 4, E-28049 Madrid, Spain Univ Autonoma Madrid Arturo Duperier 4 Madrid Spain E-28049
Citazione:
G. Camarero et al., "Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice", J NEUROSC, 21(19), 2001, pp. 7630-7641

Abstract

Insulin-like growth factor-1 (IGF-1) has been shown to play a key role during embryonic and postnatal development of the CNS, but Its effect on a sensory organ has not been studied in vivo. Therefore, we examined cochlear growth, differentiation, and maturation in Igf-1 gene knock-out mice at postnatal days 5 (P5), P8, and P20 by using stereological methods and immunohistochemistry. Mutant mice showed reduction in size of the cochlea and cochlear ganglion. An immature tectorial membrane and a significant decrease in the number and size of auditory neurons were also evident at P20. IGF-1-deficient cochlear neurons showed increased caspase-3-mediated apoptosis, along with aberrant expression of the early neural markers nestin and Islet 1/2. Cochlear ganglion and fibers innervating the sensory cells of the organ of Corti presented decreased levels of neurofilament and myelin P-o in P20 mouse mutants. In addition, an abnormal synaptophysin expression in the somataof cochlear ganglion neurons and sensory hair cells suggested the persistence of an immature pattern of synapses distribution in the organ of Corti of these animals. These results demonstrate that lack of IGF-1 in mice severely affects postnatal survival, differentiation, and maturation of the cochlear ganglion cells and causes abnormal innervation of the sensory cells inthe organ of Corti.

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Documento generato il 29/11/20 alle ore 09:50:47