Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Altered regulation of gene and protein expression of hypothalamic-pituitary-adrenal axis components in an immature rat model of chronic stress
Autore:
Avishai-Eliner, S; Gilles, EE; Eghbal-Ahmadi, M; Bar-El, Y; Baram, TZ;
Indirizzi:
Univ Calif Irvine, ZOT 4475, Dept Anat Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 nat Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 , Dept Pediat, Irvine, CA 92697 USA Hebrew Univ Jerusalem, Jerusalem, Israel Hebrew Univ Jerusalem JerusalemIsrael niv Jerusalem, Jerusalem, Israel Kaplan Med Ctr, Rehovot, Israel Kaplan Med Ctr Rehovot IsraelKaplan Med Ctr, Rehovot, Israel Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 Pediat, Minneapolis, MN 55455 USA Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 Neurol, Minneapolis, MN 55455 USA
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 9, volume: 13, anno: 2001,
pagine: 799 - 807
SICI:
0953-8194(200109)13:9<799:AROGAP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; MESSENGER-RNA EXPRESSION; PARAVENTRICULAR NUCLEUS; DIFFERENTIAL REGULATION; MATERNAL-DEPRIVATION; FACTOR RECEPTORS; NEONATAL RAT; INFANT RAT; REPEATED RESTRAINT; HORMONE;
Keywords:
corticotropin releasing hormone; chronic stress; neonatal rat; CRF; glucocorticoid receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Baram, TZ Univ Calif Irvine, ZOT 4475, Dept Anat Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 iol, Irvine, CA 92697 USA
Citazione:
S. Avishai-Eliner et al., "Altered regulation of gene and protein expression of hypothalamic-pituitary-adrenal axis components in an immature rat model of chronic stress", J NEUROENDO, 13(9), 2001, pp. 799-807

Abstract

Chronic stress early in postnatal life influences hormonal and behaviouralresponses to stress persistently, but the mechanisms and molecular cascades that are involved in this process have not been clarified. To approach these issues, a chronic stress paradigm for the neonatal rat, using limited bedding material to alter the cage environment, was devised. In 9-day-old rats subjected to this chronic stress for 1 week, significant and striking changes in the expression and release patterns of key molecules that govern the neuroendocrine stress responses were observed. The presence of sustainedstress was evident from enhanced activation of peripheral elements of the neuroendocrine stress response, i.e. increased basal plasma corticosterone concentrations, high adrenal weight and decreased body weight. Central regulatory elements of the neuroendocrine stress response were perturbed, including reduced expression of hypothalamic corticotropin-releasing hormone that, surprisingly, was accompanied by reduced glucocorticoid receptor expression. Thus, the effects of chronic sustained stress in the neonatal rat on the hypothalamic-pituitary-adrenal axis included substantial changes in the expression and activity of major regulators of this axis. Importantly, the changes induced by this chronic stress differed substantially from those related to acute or recurrent stress, providing a novel model for studying the long-term effects of chronic, early life stress on neuroendocrine functions throughout life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:39:59