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Titolo:
Regulation of rat adrenal vasoactive intestinal peptide content: Effects of adrenocorticotropic hormone treatment and changes in dietary sodium intake
Autore:
Hinson, JP; Renshaw, D; Carroll, M; Kapas, S;
Indirizzi:
Barts & London Queen Mary Sch Med & Dent, Dept Endocrinol, Div Gen & Dev Med, London EC1A 7BE, England Barts & London Queen Mary Sch Med & Dent London England EC1A 7BE England Barts & London Queen Mary Sch Med & Dent, Clin Sci Res Ctr, London EC1A 7BE, England Barts & London Queen Mary Sch Med & Dent London England EC1A 7BE England
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 9, volume: 13, anno: 2001,
pagine: 769 - 773
SICI:
0953-8194(200109)13:9<769:RORAVI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE-Y; GLAND; ALDOSTERONE; POLYPEPTIDE; SECRETION; CORTEX; VIP; CATECHOLAMINES; LOCALIZATION; CELLS;
Keywords:
adrenal cortex; zona glomerulosa; adrenal medulla; VIP; neuropeptides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Hinson, JP Barts & London Queen Mary Sch Med & Dent, Dept Endocrinol, Div Gen & Dev Med, Suite 12,Domin House,Bartholomew Close, London EC1A 7BE, England Barts & London Queen Mary Sch Med & Dent Suite 12,Domin House,Bartholomew Close London England EC1A 7BE
Citazione:
J.P. Hinson et al., "Regulation of rat adrenal vasoactive intestinal peptide content: Effects of adrenocorticotropic hormone treatment and changes in dietary sodium intake", J NEUROENDO, 13(9), 2001, pp. 769-773

Abstract

Vasoactive intestinal peptide (VIP) is well established as a paracrine regulator of adrenal function. It is present in nerves supplying the adrenal cortex, although previous studies have found that the amount of VIP in the outer zones of the rat adrenal is not affected by ligating the splanchnic nerve supplying the adrenal gland. The present studies were designed to investigate the mechanisms involved in regulating the VIP content of the rat adrenal gland. This study examined the effects of changes in electrolyte balance and adrenocorticotropic hormone (ACTH) administration on the adrenal content of VIP as measured by radioimmunoassay. Rats on a low sodium diet had a significantly increased capsular/zona glomerulosa immunoreactive VIP (irVIP) level, while rats on a high sodium diet had suppressed levels relative to controls. Changes in dietary sodium did not affect inner zone/medullary VIP content. Administration of ACTH caused a decrease in irVIP levels in the capsular/zona glomerulosa portion of the adrenal gland but had no effect on the inner zone/medulla. Analysis of mRNA encoding VIP revealed a large increase in expression of VIP in the sodium-deplete group compared with the control, with no change in VIP expression in the sodium-loaded group. ACTH treatment was found to significantly decrease VIP mRNA levels in the capsular portion. Neither ACTH treatment nor changes in sodium intake affected inner zones/medullary VIP message. These data suggest that VIP in the capsuleand zona glomerulosa region of the adrenal cortex is regulated in responseto the physiological status of the animal, with changes in capsular/zona glomerulosa VIP correlating with changes in zona glomerulosa function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:20:02