Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Na+: HCO3- cotransporters (NBC): Cloning and characterization
Autore:
Soleimani, M; Burnham, CE;
Indirizzi:
Univ Cincinnati, Dept Med, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 ept Med, Cincinnati, OH 45267 USA Vet Affairs Med Ctr, Cincinnati, OH 45267 USA Vet Affairs Med Ctr Cincinnati OH USA 45267 Ctr, Cincinnati, OH 45267 USA
Titolo Testata:
JOURNAL OF MEMBRANE BIOLOGY
fascicolo: 2, volume: 183, anno: 2001,
pagine: 71 - 84
SICI:
0022-2631(20010915)183:2<71:NHC(CA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM-BICARBONATE COTRANSPORTER; ELECTROGENIC NA+-HCO3 COTRANSPORTER; BASOLATERAL MEMBRANE-VESICLES; RENAL NA-HCO3 COTRANSPORTER; PERITUBULAR CELL-MEMBRANE; LUMINAL NA+/H+ EXCHANGE; ACID-BASE METABOLISM; PROXIMAL TUBULE; RAT-KIDNEY; FUNCTIONAL-CHARACTERIZATION;
Keywords:
Na+: HCO3- cotransporter; kidney pancreas; CFTR; acid-base regulation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Soleimani, M Univ Cincinnati, Dept Med, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 innati, OH 45267 USA
Citazione:
M. Soleimani e C.E. Burnham, "Na+: HCO3- cotransporters (NBC): Cloning and characterization", J MEMBR BIO, 183(2), 2001, pp. 71-84

Abstract

The sodium bicarbonate cotransporter (NBC I) is essential for bicarbonate transport across plasma membranes in epithelial and nonepithelial cells. The direction of the NaHCO3 movement in secretory epithelia is opposite to that in reabsorptive epithelia. In secretory epithelia (such as pancreatic duct cells) NBC is responsible for the transport of bicarbonate from blood tothe cell for eventual secretion at the apical membrane. In reabsorptive epithelia (such as kidney proximal tubule cells) NBC is responsible for the reabsorption of bicarbonate from cell to the blood. In nonepithelial cells this transporter is mainly involved with cell pH regulation. Recent molecular cloning experiments have identified the existence of four NBC isoforms (NBC1, 2, 3 and 4) and two NBC-related proteins AE4 and NCBE (Anion Exchanger4 and Na-dependent Chloride-Bicarbonate Exchanger). All but AE4 are presumed to mediate the cotransport of Na+ and HCO3- under normal conditions and may be functionally altered in certain pathologic states. NBC1 shows a limited tissue expression pattern, is electrogenic and plays an important role in bicarbonate reabsorption in kidney proximal tubule. In addition to the kidney, NBC1 is expressed in pancreatic duct cells, is activated by cystic fibrosis trans membrane conductance regulator (CFTR) and plays an important role in HCO3- secretion. NBC2 and NBC3 have a wider tissue distribution than NBC1, are electroneutral, and are involved with cell pH regulation. The characterization of NBC4 is incomplete. The NBC-related protein called NCBE mediates Na-dependent, Cl-/Bicarbonate Exchange. The purpose of this reviewis to summarize recent advances on the cloning of NBC isoforms and relatedproteins and their role and regulation in physiologic and pathologic states.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:28:53