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Titolo:
A new polysaccharide macromolecular contrast agent for MR imaging: Biodistribution and imaging characteristics
Autore:
Helbich, TH; Gossman, A; Mareski, PA; Raduchel, B; Roberts, TPL; Shames, DM; Muhler, M; Turetschek, K; Brasch, RC;
Indirizzi:
Univ Calif San Francisco, Dept Radiol, Contrast Media Lab, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF MAGNETIC RESONANCE IMAGING
fascicolo: 6, volume: 11, anno: 2000,
pagine: 694 - 701
SICI:
1053-1807(200006)11:6<694:ANPMCA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE ANGIOGRAPHY; GADOLINIUM-DTPA COMPLEX; GD-DTPA; CAPILLARY-PERMEABILITY; TUMOR GRADE; RAT; MEDIA; BLOOD; QUANTIFICATION; DIRECTIONS;
Keywords:
magnetic resonance imaging; contrast agents; gadolinium; experimental studies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Brasch, RC Univ Calif San Francisco, Dept Radiol, Contrast Media Lab, S-372,Box 0628,San Francisco, CA 94143 USA Univ Calif San Francisco S-372,Box 0628 San Francisco CA USA 94143
Citazione:
T.H. Helbich et al., "A new polysaccharide macromolecular contrast agent for MR imaging: Biodistribution and imaging characteristics", J MAGN R I, 11(6), 2000, pp. 694-701

Abstract

The aims of this study were to characterize certain physicochemical, pharmacokinetic, and enhancement properties of a new macromolecular contrast agent, carboxymethyl hydroxyethyl starch-(Gd-DO3A)(35) [CMHES-(Gd-DO3A)(35)], consisting of a polysaccharide backbone covalently derivatized with multiple macrocyclic chelating groups for gadolinium. CMHES-(Gd-DO3A)(35) has an average molecular weight of 72 kD and a plasma half-time of 8.4 hours. T1 and T2 relaxivities are 14.1 +/- 0.1 L mmol(-1) . sec(-1) and 17.8 +/- 0.9 L mmol(-1) . sec(-1). respectively, for each gadolinium. ion measured at 39 degreesC and 20 Mhz; this T1 relaxivity is more than 4 times that of gadopentetate. Seven days after intravenous administration only relatively small amounts of gadolinium. could be detected in blood or other tissues of rats. The compound was well tolerated in diagnostic dosages by all experimental animals. Magnetic resonance angiography performed within 1 hour of CMHES-(Gd-DO3A)(35) administration showed a near-constant and strong enhancement of blood in arteries and veins. Analysis of dynamic enhancement patterns of experimental tumors (MAT-LyLu prostate cancer implanted in rats) following intravenous CHMES-(Gd-DO3A)(35) administration yielded quantitative estimatesof tumor plasma volume and microvessel permeability; the demonstrated hyperpermeability of tumor microvessels was easily distinguished from the absence of measurable microvascular permeability In non-neoplastic soft tissues. J. Magn. Reson. Imaging 2000;11:694-701. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:55:57