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Titolo:
Slow clearance gadolinium-based extracellular and intravascular contrast media for three-dimensional MR angiography
Autore:
Bremerich, J; Colet, JM; Giovenzana, GB; Aime, S; Scheffler, K; Laurent, S; Bongartz, G; Muller, RN;
Indirizzi:
Univ Basel Hosp, Dept Radiol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ol, CH-4031 Basel, Switzerland
Titolo Testata:
JOURNAL OF MAGNETIC RESONANCE IMAGING
fascicolo: 4, volume: 13, anno: 2001,
pagine: 588 - 593
SICI:
1053-1807(200104)13:4<588:SCGEAI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE ANGIOGRAPHY; AGENT NC100150 INJECTION; GD-DTPA; DISTRIBUTION VOLUME; MYOCARDIAL VIABILITY; ECHO-PLANAR; REPERFUSION; ISCHEMIA; MS-325;
Keywords:
intravascular contrast media; extracellular contrast media; three-dimensional MR angiography; myocardial viability; gadolinium chelates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Bremerich, J Univ Basel Hosp, Dept Radiol, Petersgraben 4, CH-4031 Basel, Switzerland Univ Basel Hosp Petersgraben 4 Basel Switzerland CH-4031 and
Citazione:
J. Bremerich et al., "Slow clearance gadolinium-based extracellular and intravascular contrast media for three-dimensional MR angiography", J MAGN R I, 13(4), 2001, pp. 588-593

Abstract

The objective of this study was to assess two new slow-clearance contrast media with extracellular and intravascular distribution for magnetic resonance angiography (MRA). Extracellular Gd-DTPA-BC(2)glucA and intravascular Gd(DO3A)(3)-lys(16) were developed within the European Biomed2 MACE Program and compared with two reference compounds, intravascular CMD-A2-Gd-DOTA andextracellular GdDOTA, in 12 rats. Pre- and post-contrast three-dimensionalMR (TR/TE = 5 msec/2.2 msec; isotropic voxel size 0.86 mm(3)) was acquiredfor 2 hours. Signal-to-noise enhancement (Delta SNR) was calculated. Two minutes after injection, all contrast media provided strong vascular signal enhancement. The Delta SNR for Gd-DTPA-BC2glucA, Gd(DO3A)(3)-lys(16), CMD-A2-Gd-DOTA, and GdDOTA were 13.0 +/- 1.8, 25.0 +/- 3.2, 25.0 +/- 4.0, and 18.0 +/- 3.4, respectively. Gd-DTPA-BC(2)glucA, Gd(DO3A)(3)-lys(16), and CMD-A2-Gd-DOTA cleared slowly from the circulation, whereas GdDOTA cleared rapidly. Vascular Delta SNR at 2 hours were 2.9 +/- 0.6, 25.0 +/- 3.2, 25.0 +/-4.0, and 0.4 +/- 1.0. Gd(DO3A)(3)-lys(16) provided strong vascular and minor background enhancement, and thus may be useful for MRA or perfusion imaging. Gd-DTPA-BC2glucA produces persistent enhancement of extracellular water, and thus may allow quantification of extracellular distribution volume and assessment of myocardial viability. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 20:11:10