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Titolo:
Tumor microvascular characterization using ultrasmall superparamagnetic iron oxide particles (USPIO) in an experimental breast cancer model
Autore:
Turetschek, K; Roberts, TPL; Floyd, E; Preda, A; Novikov, V; Shames, DM; Carter, WO; Brasch, RC;
Indirizzi:
Univ Calif San Francisco, Dept Radiol, Ctr Pharmaceut & Mol Imaging, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF MAGNETIC RESONANCE IMAGING
fascicolo: 6, volume: 13, anno: 2001,
pagine: 882 - 888
SICI:
1053-1807(200106)13:6<882:TMCUUS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR CONTRAST-MEDIA; GD-DTPA; PROGNOSTIC VALUE; AGENT; GRADE; ANGIOGENESIS; PERMEABILITY; ANGIOGRAPHY; RATS;
Keywords:
magnetic resonance imaging; breast neoplasms; contrast media; microvascular density; histologic tumor grade;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Roberts, TPL Univ Calif San Francisco, Dept Radiol, Ctr Pharmaceut & Mol Imaging, 505 Parnassus Ave, San Francisco, CA 94143 USA Univ Calif San Francisco 505 Parnassus Ave San Francisco CA USA 94143
Citazione:
K. Turetschek et al., "Tumor microvascular characterization using ultrasmall superparamagnetic iron oxide particles (USPIO) in an experimental breast cancer model", J MAGN R I, 13(6), 2001, pp. 882-888

Abstract

The diagnostic potential of ultrasmall superparamagnetic iron oxide particles (USPIO) for quantitative tumor microvessel characterization was assessed by kinetic analysis of dynamic magnetic resonance imaging (MRI) in a rodent breast cancer model. Microvascular characteristics (transendothelial permeability (K-PS) and fractional plasma volume (fPV)) were estimated in 32 female Sprague Dawley rats, bearing breast tumors of varying malignancy. These values were compared to a prototype macromolecular contrast medium standard, albumin-(GdDTPA)(30). Transendothelial permeability (K-PS) correlated significantly (P < 0.05) with the tumor grade (Scarff-Bloom-Richardson (SBR) score) for the USPIO (r = 0.36), as well as for the reference macromolecule, albumin-(GdDTPA)(30) (r = 0.54). Estimates for the fPV did not show a statistically significant correlation with the tumor grade for either contrast medium. In conclusion, USPIO-enhanced NM data were capable to characterize tumor microvessel properties in this breast cancer model: microvascular permeability (determined using USPIO) correlated significantly with tumor grade. Thus, quantitative estimation of microvascular characteristics in tumors could provide a surrogate of new vessel formation (angiogenesis) and thus a further important clinical Indication for USPIO, in addition to MR angiography. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:35:30