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Titolo:
A new gadolinium-based contrast agent for magnetic resonance imaging of brain tumors: Kinetic study on a C6 rat glioma model
Autore:
Fonchy, E; Lahrech , H; Francois-Joubert, A; Dupeyre, R; Benderbous, S; Corot, C; Farion, R; Rubin, C; Decorps, M; Remy, C;
Indirizzi:
Univ Grenoble 1, Unite Mixte INSERM, RMN Bioclin, U438,LRC,CEA,Hop Albert Michallon, Grenoble, France Univ Grenoble 1 Grenoble France ,Hop Albert Michallon, Grenoble, France
Titolo Testata:
JOURNAL OF MAGNETIC RESONANCE IMAGING
fascicolo: 2, volume: 14, anno: 2001,
pagine: 97 - 105
SICI:
1053-1807(200108)14:2<97:ANGCAF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENHANCED MR; GD-DTPA; BARRIER PERMEABILITY; WATER PROTONS; BLOOD; RELAXATION; PARAMETERS; DEPENDENCE; DIFFUSION;
Keywords:
contrast agents; contrast enhancement; magnetic resonance imaging; C6 glioma; pharmacokinetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Remy, C CHU Grenoble, INSERM U438 RMN Bioclin, Pavillon B,BP 217, F-38043 Grenoble09, France CHU Grenoble Pavillon B,BP 217 Grenoble France 09 noble09, France
Citazione:
E. Fonchy et al., "A new gadolinium-based contrast agent for magnetic resonance imaging of brain tumors: Kinetic study on a C6 rat glioma model", J MAGN R I, 14(2), 2001, pp. 97-105

Abstract

T-1-weighted magnetic resonance imaging (MRI) was used to evaluate the potential interest of a new Gd-based contrast agent, termed P760, to characterize brain tumor heterogeneity and vascularization and to delineate regions containing permeable vessels. The C6 rat glioma model was used as a model of high-grade glioblastoma. The signal enhancement was measured as a function of time in the vascular compartment and In different regions of Interest (RoIs) within the tumor after the injection of 0.02 mmol kg(-1) of P760. The results were compared to those obtained after the injection of 0.1 mmol kg(-1) of Gd-DOTA. We showed that P760, in spite of a Gd concentration five times smaller, produces an enhancement in the blood pool similar to that produced by Gd-DOTA. It was shown that P760 makes possible an excellent delineation of regions containing vessels with a damaged blood-brain barrier (BBB). Images acquired 5-10 minutes after P760 Injection showed the location of permeable vessels more accurate than Gd-DOTA-enhanced images. The enhancement produced in the tumor by P760 was, however, less than that produced byGd-DOTA. The extravasation and/or diffusion rate of P760 in the interstitial medium were found to be strongly reduced, compared to those found with Gd-DOTA. This study suggests that the new contrast agent has promising capabilities in clinical imaging of brain tumors. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:17:21