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Titolo:
Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by V gamma 9/V delta 2 T lymphocytes
Autore:
Dieli, F; Troye-Blomberg, M; Ivanyi, J; Fournie, JJ; Krensky, AM; Bonneville, M; Peyrat, MA; Caccamo, N; Sireci, G; Salerno, A;
Indirizzi:
Univ Palermo, Dipartimento Biopatol, I-90134 Palermo, Italy Univ Palermo Palermo Italy I-90134 ento Biopatol, I-90134 Palermo, Italy Italian Natl Res Council, Ist Metodol Diagnost, Palermo, Italy Italian Natl Res Council Palermo Italy Metodol Diagnost, Palermo, Italy Univ Stockholm, Dept Immunol, S-10691 Stockholm, Sweden Univ Stockholm Stockholm Sweden S-10691 munol, S-10691 Stockholm, Sweden Univ London Kings Coll, Guys Hosp, Sch Med & Dent, Dept Oral Med & Pathol,London, England Univ London Kings Coll London England Oral Med & Pathol,London, England Ctr Hosp Univ Purpan, INSERM, U395, Toulouse, France Ctr Hosp Univ PurpanToulouse France an, INSERM, U395, Toulouse, France Inst Biol, INSERM, U463, Nantes, France Inst Biol Nantes FranceInst Biol, INSERM, U463, Nantes, France Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA Stanford UnivStanford CA USA 94305 , Dept Pediat, Stanford, CA 94305 USA
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 8, volume: 184, anno: 2001,
pagine: 1082 - 1085
SICI:
0022-1899(20011015)184:8<1082:GKOIAE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIMICROBIAL ACTIVITY; CELLS; PREDOMINANCE; INFECTION; SUBSET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Salerno, A Univ Palermo, Dipartimento Biopatol, Corso Tukory 211, I-90134 Palermo, Italy Univ Palermo Corso Tukory 211 Palermo Italy I-90134 rmo, Italy
Citazione:
F. Dieli et al., "Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by V gamma 9/V delta 2 T lymphocytes", J INFEC DIS, 184(8), 2001, pp. 1082-1085

Abstract

Contribution of V gamma9/V delta2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that V gamma9/V delta2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that V gamma9/V delta2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in V gamma9/V delta2 T lymphocytes, play a major role, which indicates that V gamma9/V deltaT lymphocytes directly contribute to a protective host response against M. tuberculosis infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:30:03