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Titolo:
Cytomegalovirus-specific cellular immune responses and viremia in recipients of allogeneic stem cell transplants
Autore:
Aubert, G; Hassan-Walker, AF; Madrigal, JA; Emery, VC; Morte, C; Grace, S; Koh, MBC; Potter, M; Prentice, HG; Dodi, IA; Travers, PJ;
Indirizzi:
Royal Free & Univ Coll Med Sch, Dept Haematol, Anthony Nolan Res Inst, London NW3 2QG, England Royal Free & Univ Coll Med Sch London England NW3 2QG n NW3 2QG, England Royal Free & Univ Coll Med Sch, Dept Virol, London NW3 2QG, England Royal Free & Univ Coll Med Sch London England NW3 2QG n NW3 2QG, England Royal Free & Univ Coll Med Sch, Dept Haematol, London NW3 2QG, England Royal Free & Univ Coll Med Sch London England NW3 2QG n NW3 2QG, England
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 8, volume: 184, anno: 2001,
pagine: 955 - 963
SICI:
0022-1899(20011015)184:8<955:CCIRAV>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW-TRANSPLANT; POLYMERASE CHAIN-REACTION; CMV DISEASE; IMMUNOCOMPROMISED PATIENTS; VIRUS INFECTIONS; T-LYMPHOCYTES; PROTEIN PP65; IN-VIVO; GANCICLOVIR; PROPHYLAXIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Madrigal, JA Royal Free & Univ Coll Med Sch, Dept Haematol, Anthony Nolan Res Inst, Royal Free Campus,Fleet Rd, London NW3 2QG, England Royal Free & Univ Coll Med Sch Royal Free Campus,Fleet Rd London England NW3 2QG
Citazione:
G. Aubert et al., "Cytomegalovirus-specific cellular immune responses and viremia in recipients of allogeneic stem cell transplants", J INFEC DIS, 184(8), 2001, pp. 955-963

Abstract

The immune suppression inherent in allogeneic stem cell transplantation (SCT) offers a favorable environment for infection by opportunistic agents, such as human cytomegalovirus (CMV). Despite the application of potent antiviral prophylaxis, patients remain at risk for CMV infection until adequate immunity is restored. CMV-specific CD8(+) T cell counts were monitored, using HLA-A2 tetrameric complexes, to establish the level of immune response to the viral phosphoprotein UL83 in patients after allogeneic SCT. Correlating this with viral replication and clinical status shows that the level of tetramer-positive T cells provides an assessment of CMV immune reconstitution after stem cell transplantation. Most patients with seropositive donors did reconstitute long-term CMV immunity, unless prolonged immunosuppressionto control graft-versus-host disease was induced. Together with polymerasechain reaction testing, this technique provides measurable parameters thatcan be a guide to therapeutic decision making and can form the basis of CMV immunotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:47:08