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Titolo:
Linkage disequilibrium and haplotype analysis among four novel single-nucleotide polymorphisms in the human leukemia inhibitory factor (LIF) gene
Autore:
Ishida, R; Ezura, Y; Iwasaki, H; Nakazawa, I; Kajita, M; Kodaira, M; Ito, H; Emi, M;
Indirizzi:
Nippon Med Coll, Inst Gerontol, Dept Mol Biol, Nakahara Ku, Kawasaki, Kanagawa 2118533, Japan Nippon Med Coll Kawasaki Kanagawa Japan 2118533 , Kanagawa 2118533, Japan Nippon Med Coll, Dept Orthoped, Nakahara Ku, Kawasaki, Kanagawa 2118533, Japan Nippon Med Coll Kawasaki Kanagawa Japan 2118533 , Kanagawa 2118533, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 10, volume: 46, anno: 2001,
pagine: 557 - 559
SICI:
1434-5161(2001)46:10<557:LDAHAA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA REPEAT SEQUENCE; LOCUS;
Keywords:
leukemia inhibitory factor (LIF); single-nucleotide polymorphism; Japanese population; direct sequence; haplotype frequency; linkage disequilibrium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Emi, M Nippon Med Coll, Inst Gerontol, Dept Mol Biol, Nakahara Ku, 1-396 Kosugicho, Kawasaki, Kanagawa 2118533, Japan Nippon Med Coll 1-396 KosugichoKawasaki Kanagawa Japan 2118533 pan
Citazione:
R. Ishida et al., "Linkage disequilibrium and haplotype analysis among four novel single-nucleotide polymorphisms in the human leukemia inhibitory factor (LIF) gene", J HUM GENET, 46(10), 2001, pp. 557-559

Abstract

Leukemia inhibitory factor (LIF) is a pleiotropic cytokine implicated in various pathological conditions, such as rheumatoid arthritis and osteoporosis. Despite the possible importance of LIF as a therapeutic target, little is known about the bioregulation of the human LIF gene. We here sequenced the entire structure of the LIF gene of 48 alleles in the Japanese population. These experiments identified four single-nucleotide polymorphisms (SNPs)and determined their allelic frequencies from a 48-allele sequence in the Japanese population. All four SNPs found in the LIF gene were located within exon 3, that is, a C/T at nucleotide (nt) position 3951, a C/G at nt position 4376, an A/C at nt position 4442, and a G/A at nt position 5961 (nucleotide numbering starts from the ATG start codon). Based on the genotypic data, we constructed four major haplotypes in the tested population. Two-way comparisons of SNPs revealed complete linkage disequilibrium between SNPs at positions 3951, 4376, and 4442. These results may prove to be useful as genetic markers for population-based disease-association studies in osteoporosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 09:47:34