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Titolo:
Characteristic features and ligand specificity of the two olfactory receptor classes from Xenopus laevis
Autore:
Mezler, M; Fleischer, J; Breer, H;
Indirizzi:
Univ Hohenheim, Inst Psychol, D-70593 Stuttgart, Germany Univ Hohenheim Stuttgart Germany D-70593 hol, D-70593 Stuttgart, Germany Bayer AG, Ctr Agr, MWF, Monheim, Germany Bayer AG Monheim GermanyBayer AG, Ctr Agr, MWF, Monheim, Germany
Titolo Testata:
JOURNAL OF EXPERIMENTAL BIOLOGY
fascicolo: 17, volume: 204, anno: 2001,
pagine: 2987 - 2997
SICI:
0022-0949(200109)204:17<2987:CFALSO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; ODORANT RECEPTOR; CHANNEL CATFISH; FUNCTIONAL EXPRESSION; ICTALURUS-PUNCTATUS; AMINO-ACIDS; K+-CHANNEL; ELECTRO-OLFACTOGRAM; NEURONS; RESPONSES;
Keywords:
olfactory receptor; Xenopus laevis; sequence analysis; oocyte; heterologous expression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Breer, H Univ Hohenheim, Inst Psychol, D-70593 Stuttgart, Germany Univ Hohenheim Stuttgart Germany D-70593 593 Stuttgart, Germany
Citazione:
M. Mezler et al., "Characteristic features and ligand specificity of the two olfactory receptor classes from Xenopus laevis", J EXP BIOL, 204(17), 2001, pp. 2987-2997

Abstract

Amphibia have two classes of olfactory receptors (ORs), class I (fish-likereceptors) and class II (mammalian-like receptors). These two receptor classes correspond to the two classes identified in other vertebrates, and amphibians thus provide a unique opportunity to compare olfactory receptors ofboth classes in one animal species, without the constraints of evolutionary distance between different vertebrate orders, such as fish and mammals. We therefore identified the complete open reading frames of class I and class II ORs in Xenopus laevis. In addition to allowing a representative comparison of the deduced amino acid sequences between both receptor classes, we were also able to perform differential functional analysis. These studies revealed distinct class-specific motifs, particularly in the extracellular loops 2 and 3, which might be of importance for the interaction with odorants, as well as in the intracellular loops 2 and 3, which might be responsible for interactions with specific G-proteins. The results of functional expression studies in Xenopus oocytes, comparing distinct receptor types, support the idea that class I receptors are activated by water-soluble odorants,whereas class II receptors are activated by volatile compounds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 13:09:00