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Titolo:
Effects of Korean red ginseng and its mixed prescription on the high molecular weight dextran-induced blood stasis in rats and human platelet aggregation
Autore:
Yun, YP; Do, JH; Ko, SR; Ryu, SY; Kim, JH; Song, HC; Park, YD; Ahn, KS; Kim, SH;
Indirizzi:
Kyung Hee Univ, Grad Sch E W Med Sci, Dept Oncol, Yongin 449701, South Korea Kyung Hee Univ Yongin South Korea 449701 col, Yongin 449701, South Korea Kyung Hee Univ, Plant Metab Res Ctr, Yongin 449701, South Korea Kyung Hee Univ Yongin South Korea 449701 Ctr, Yongin 449701, South Korea Kyung Hee Univ, Sch Biotechnol, Yongin 449701, South Korea Kyung Hee UnivYongin South Korea 449701 nol, Yongin 449701, South Korea Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea Chungbuk NatlUniv Cheongju South Korea 361763 ongju 361763, South Korea Korea Ginseng & Tobacco Res Inst, Taejon 305345, South Korea Korea Ginseng& Tobacco Res Inst Taejon South Korea 305345 , South Korea Korea Res Inst Chem Technol, Taejon 305343, South Korea Korea Res Inst Chem Technol Taejon South Korea 305343 05343, South Korea Chosun Univ, Jr Coll Nursing, Kwang 501140, South Korea Chosun Univ Kwang South Korea 501140 Nursing, Kwang 501140, South Korea Kyung Hee Univ, Oriental Med Coll, Seoul 130701, South Korea Kyung Hee Univ Seoul South Korea 130701 Coll, Seoul 130701, South Korea
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 2-3, volume: 77, anno: 2001,
pagine: 259 - 264
SICI:
0378-8741(200110)77:2-3<259:EOKRGA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Keywords:
Korean red ginseng; KRGP; platelet aggregation; coagulation; blood stasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, SH Kyung Hee Univ, Grad Sch E W Med Sci, Dept Oncol, 1 Seochun Ri, Yongin 449701, South Korea Kyung Hee Univ 1 Seochun Ri Yongin South Korea 449701 South Korea
Citazione:
Y.P. Yun et al., "Effects of Korean red ginseng and its mixed prescription on the high molecular weight dextran-induced blood stasis in rats and human platelet aggregation", J ETHNOPHAR, 77(2-3), 2001, pp. 259-264

Abstract

This study was undertaken to evaluate the antithrombotic. effects of Korean Red Ginseng (KRG) and its new prescription (KRGP) consisting of five herbs such as Korean red ginseng, Ganoderma, Cinnamomi Cortex, Glycyrrhizae Radix and Laminaria. In rats with blood stasis induced by high molecular weight dextran, KRG and KRGP significantly restored not only the number of platelets and fibrinogen, but also suppressed the fibrin degradation products (FDP) to normal range. In platelet aggregation assay with human platelet richplasma (PRP), KRG and KRGP significantly inhibited thrombin and collagen-induced platelet aggregation. The IC50 values of KRG and KRGP were >2 and 0.23 +/- 0.01 mg/ml for thrombin, 0.32 +/- 0.01 and 0.17 +/- 0.02 mg/ml for collagen and 0.72 +/- 0.25 and >2 mg/ml for ADP, respectively. In coagulation assay, KRG and KRGP significantly prolonged activated partial prothrombintime (APPT) and prothrombin time (PT) as compared with control data. KRGP was found to be more effective than KRG alone on antithrombotic activity. These results suggest that KRGP may exert its antithrombotic activity due toinhibition of platelet aggregation and coagulation activity more than KRG. Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 08:50:14