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Titolo:
Effect of silibinin and vitamin E on restoration of cellular immune response after partial hepatectomy
Autore:
Horvath, ME; Gonzalez-Cabello, R; Blazovics, A; van der Looij, M; Barta, I; Muzes, G; Gergely, N; Feher, J;
Indirizzi:
Semmelweis Univ Med, Dept Med 2, H-1088 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1088 2, H-1088 Budapest, Hungary Natl Inst Dermatol & Venerol, Budapest, Hungary Natl Inst Dermatol & Venerol Budapest Hungary enerol, Budapest, Hungary Natl Inst Oncol, Dept Mol Biol, Budapest, Hungary Natl Inst Oncol Budapest Hungary ncol, Dept Mol Biol, Budapest, Hungary
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 2-3, volume: 77, anno: 2001,
pagine: 227 - 232
SICI:
0378-8741(200110)77:2-3<227:EOSAVE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; LIVER-REGENERATION; MESSENGER-RNA; RAT; INHIBITION; CELLS; PROLIFERATION; INTERLEUKIN-1; METABOLISM; EXPRESSION;
Keywords:
vitamin E; silibinin; partial hepatectomy; free radical; immune response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Horvath, ME Semmelweis Univ Med, Dept Med 2, Szentkiralyi Str 46, H-1088 Budapest, Hungary Semmelweis Univ Med Szentkiralyi Str 46 Budapest Hungary H-1088
Citazione:
M.E. Horvath et al., "Effect of silibinin and vitamin E on restoration of cellular immune response after partial hepatectomy", J ETHNOPHAR, 77(2-3), 2001, pp. 227-232

Abstract

Our aim was to study the antioxidant and immunomodulatory effect of silibinin and vitamin E on the early postoperative course in rats that had undergone a partial hepatectomy (PHX). Male Wistar rats that were treated with silibinin (50 mg/b.w.kg i.p.) and/or vitamin E (500 mg/b.w.kg p.o.) were randomised to undergo 70% PHX. At 72 h after operation, Concanavalin A (Con-A) induced lymphocyte proliferation, and lipopolysaccharide (LPS) induced interleukin-1 (IL-1) mitogenicity and tumour necrosis factor-alpha (TNF-alpha) cytotoxicity were measured in the spleen. In addition, total free radical scavenger capacity of the liver was analysed. In PHX animals, Con-A induced lymphocyte proliferation was significantly decreased, and both LPS induced IL-1 and TNF-alpha activity were significantly increased as compared to Sham treated animals. Treatment with silibinin and vitamin E synergistically restored both lymphocyte proliferation (P < 0.01) and cytokine activity (P <0.001) in PHX animals. In addition, silibinin and vitamin E synergistically (P < 0.001) restored total hepatic free radical scavenger capacity as well as serum levels of AST and gamma GT, that were all markedly decreased in PHX animals. Our results suggest that preoperative treatment with silibininand/or vitamin E modulates the cellular immunoresponse and restores impaired liver function following PHX, presumably through their antioxidant capacity. This may explain their beneficial effects on the postoperative course of liver repair. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 01/12/20 alle ore 13:24:35