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Titolo:
Decay-accelerating factor (DAF/CD55) is a functional active element of theLPS receptor complex
Autore:
Heine, H; Ulmer, AJ; El-Samalouti, VT; Lentschat, A; Hamann, L;
Indirizzi:
Res Ctr Borstel, Ctr Med & Biosci, D-23845 Borstel, Germany Res Ctr Borstel Borstel Germany D-23845 Biosci, D-23845 Borstel, Germany
Titolo Testata:
JOURNAL OF ENDOTOXIN RESEARCH
fascicolo: 3, volume: 7, anno: 2001,
pagine: 227 - 231
SICI:
0968-0519(2001)7:3<227:DF(IAF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL TRANSDUCING MOLECULE; PROTEIN TYROSINE KINASES; BINDING-PROTEIN; LIPOPOLYSACCHARIDE LPS; HUMAN MONOCYTES; T-CELLS; MONOCLONAL-ANTIBODIES; FACTOR CD55; CD14; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ulmer, AJ Res Ctr Borstel, Ctr Med & Biosci, Pk Allee 22, D-23845 Borstel,Germany Res Ctr Borstel Pk Allee 22 Borstel Germany D-23845 el, Germany
Citazione:
H. Heine et al., "Decay-accelerating factor (DAF/CD55) is a functional active element of theLPS receptor complex", J ENDOTOX R, 7(3), 2001, pp. 227-231

Abstract

Previously, we identified an 80 kDa membrane protein (LMP80) that is capable of binding to LPS and lipid A in the presence of LBP and sCD14. LMP80 could also be detected after immuno-coprecipitation of cell membranes with LPS and lipid A, indicating a physical contact of LMP80 and LPS/lipid A. Further analysis and peptide sequencing revealed that LMP80 is identical to CD55 (decay accelerating factor, DAF), a regulatory molecule of the complementcascade. Transfection of LPS-hyporesponsive Chinese hamster ovary (CHO) cells with human CD55 resulted in the translocation of NF-kappaB upon stimulation with LPS or lipid A. Our results demonstrate a new functional role of CD55 as a molecule able to mediate LPS-induced activation of cells that maybe part of a multimeric LPS receptor complex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:15:28