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Titolo:
Serum levels of interleukin-6 and interleukin-10 correlate with total skinthickness score in patients with systemic sclerosis
Autore:
Sato, S; Hasegawa, M; Takehara, K;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Dermatol, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan
Titolo Testata:
JOURNAL OF DERMATOLOGICAL SCIENCE
fascicolo: 2, volume: 27, anno: 2001,
pagine: 140 - 146
SICI:
0923-1811(200110)27:2<140:SLOIAI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH FACTOR-BETA; DERMAL FIBROBLASTS; GENE-EXPRESSION; GLYCOSAMINOGLYCAN PRODUCTION; TISSUE-SECTIONS; I PROCOLLAGEN; SCLERODERMA; COLLAGEN; PATHOGENESIS; FIBROSIS;
Keywords:
SSc; modified Rodnan TSS; serum levels; IL-6; IL-10;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Sato, S Kanazawa Univ, Sch Med, Dept Dermatol, 13-1 Takaramachi, Kanazawa,Ishikawa 9208641, Japan Kanazawa Univ 13-1 Takaramachi Kanazawa Ishikawa Japan 9208641 pan
Citazione:
S. Sato et al., "Serum levels of interleukin-6 and interleukin-10 correlate with total skinthickness score in patients with systemic sclerosis", J DERMA SCI, 27(2), 2001, pp. 140-146

Abstract

Various growth factors and cytokines have been suggested to play a centralrole in initiating and developing fibrosis in systemic sclerosis (SSc). Todetermine which serum levels of soluble mediators are the most relevant tothe decree of skin sclerosis in SSc, serum levels of various soluble mediators were examined by ELISA and correlated with skin thickening that was measured using modified Rodnan total skin thickness scoring (TSS) system. Serum levels of IL-4, IL-12, IL-13, tumor necrosis factor-alpha, connective tissue growth factor (CTGF), vascular endothelial growth factor, monocyte chemotactic protein-1, macrophage inflammatory protein-1 beta, soluble IL-6 receptor, and soluble L-selectin were higher in SSc patients than normal controls. Levels of IL-6, IL-10, and CTGF in patients with diffuse cutaneous SSc were higher than patients with limited cutaneous SSc and controls. Serum levels of IL-6 and IL-10 positively correlated with TSS in patients with SSc (r = 0.625, P < 0.0001 and r = 0.663, P < 0.0001, respectively). In addition, IL-10 levels significantly correlated with pulmonary fibrosis. Thus, serum levels of IL-6 and IL-10 most strongly reflect the extent of skin thickening in SSc, suggesting that levels of IL-6 and IL-10 are useful serological indicators for skin fibrosis in SSc. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:40:42