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Titolo:
A possible role of catenin dyslocalization in pemphigus vulgaris pathogenesis
Autore:
Lo Muzio, L; Pannone, G; Staibano, S; Mignogna, MD; Rubini, C; Ruocco, E; De Rosa, G; Sciubba, JJ;
Indirizzi:
Univ Ancona, Inst Dent Sci, Ancona, Italy Univ Ancona Ancona ItalyUniv Ancona, Inst Dent Sci, Ancona, Italy Univ Naples Federico II, Dept Biomorphol & Funct Sci, Pathol Unit, Naples,Italy Univ Naples Federico II Naples Italy nct Sci, Pathol Unit, Naples,Italy Univ Naples Federico II, Dept Dent Sci, Naples, Italy Univ Naples FedericoII Naples Italy o II, Dept Dent Sci, Naples, Italy Univ Ancona, Inst Pathol Anat, Ancona, Italy Univ Ancona Ancona ItalyUniv Ancona, Inst Pathol Anat, Ancona, Italy Univ Naples 2, Inst Dermatol, Naples, Italy Univ Naples 2 Naples ItalyUniv Naples 2, Inst Dermatol, Naples, Italy Johns Hopkins Med Ctr, Div Dent & Oral Med, Baltimore, MD USA Johns Hopkins Med Ctr Baltimore MD USA ent & Oral Med, Baltimore, MD USA
Titolo Testata:
JOURNAL OF CUTANEOUS PATHOLOGY
fascicolo: 9, volume: 28, anno: 2001,
pagine: 460 - 469
SICI:
0303-6987(200110)28:9<460:APROCD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR LEF-1; AMINO-ACID-SEQUENCE; CELL-CELL ADHESION; BETA-CATENIN; E-CADHERIN; DESMOSOMAL CADHERINS; PLAKOGLOBIN-BINDING; GLYCOPROTEIN-3 DESMOCOLLINS; PLASMINOGEN-ACTIVATOR; NUCLEAR-LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Lo Muzio, L Via Carelli 28, I-71100 Foggia, Italy Via Carelli 28 Foggia Italy I-71100 8, I-71100 Foggia, Italy
Citazione:
L. Lo Muzio et al., "A possible role of catenin dyslocalization in pemphigus vulgaris pathogenesis", J CUT PATH, 28(9), 2001, pp. 460-469

Abstract

Background: Pemphigus vulgaris (PV) is an autoimmune blistering disease ofthe skin and mucosa due to the presence of autoantibodies against the components of desmosomes. To date, less is known about the expression levels ofbeta- and gamma -catenins in blistering diseases. The objective of this study was to evaluate the role of beta- and gamma -catenins in the pathogenesis of acantholysis in pemphigus vulgaris. Methods: beta- and gamma -catenin expression was evaluated by immunohistochemistry in 30 cases of PV at various stages of the disease and, as controls, in 18 specimens of the skin/oral mucosa of healthy patients. Results: Healthy skin and normal oral mucosa showed a strong and gamma -catenin expression in basal and spinous layers with a prevalent cellular membrane distribution; the intensity of staining progressively decreased towardthe superficial layers of epithelium. In PV patients, cytoplasmic expression of gamma -catenin was detected in 28/30 cases, and in 19/30 cases of PV for beta -catenin. Moreover, a progressive displacement of the signal toward the nucleus was found in 14/30 cases for beta -catenin, with dyslocalization toward the nucleus, particularly in areas with intense acantholysis, and in 22/30 cases of PV for gamma -catenin. Conclusions: Abnormal distribution of gamma -catenin, consequent to PV IgG, may be considered a direct consequence of Dg3 dissociation from catenin. gamma -catenin likely plays a direct role in PV pathogenesis through its dyslocalization toward the nucleus or indirectly through the beta -catenin dyslocalization toward the nucleus, which is thought to induce transcription of selected target genes, such as uPAR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 05:55:35