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Titolo:
Tumor-infiltrating T cells in primary cutaneous B-cell lympho-proliferative disorders
Autore:
Kamarashev, J; Schaerer, L; Burg, G; Schmid, MH; Muller, B; Kempf, W;
Indirizzi:
Univ Zurich, Dept Dermatol, CH-8091 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8091 atol, CH-8091 Zurich, Switzerland
Titolo Testata:
JOURNAL OF CUTANEOUS PATHOLOGY
fascicolo: 9, volume: 28, anno: 2001,
pagine: 448 - 452
SICI:
0303-6987(200110)28:9<448:TTCIPC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSEUDOLYMPHOMAS; VACCINATION; POPULATION; CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kempf, W Univ Zurich, Dept Dermatol, Gloriastr 31, CH-8091 Zurich, Switzerland Univ Zurich Gloriastr 31 Zurich Switzerland CH-8091 Switzerland
Citazione:
J. Kamarashev et al., "Tumor-infiltrating T cells in primary cutaneous B-cell lympho-proliferative disorders", J CUT PATH, 28(9), 2001, pp. 448-452

Abstract

Background: Tumor-infiltrating lymphocytes (TILs) are considered to play an important role in the antitumoral immune response. The presence and percentage of CD8-positive tumor-infiltrating T cells have been shown to correlate with differentiation and prognosis in various neoplasms. The aim of thisstudy was to determine the number of CD8-positive T cells in various primary cutaneous B-cell lymphoproliferative disorders and to evaluate its correlation with the histological type of tumor. Methods: Fifty-three lesions were examined by immunohistochemistry with antibodies targeting CD3, CD4, CD8 and TIA-1. Thirty-two lesions had been diagnosed as primary cutaneous B-cell lymphomas (CBCL) and 21 as B-cell pseudolymphomas (B-PSL). CBCLs included 15 follicular lymphomas (FL), 6 marginal zone lymphomas (MZL), and 11 diffuse large B-cell lymphomas (LCL). The number of CD8-positive cytotoxic T cells was determined by computer-assisted morphometrical microscopy. Results: No significant difference could be detected in the density of CD8-positive T cells in B-PSL (101/10(5) mum(2)), FL (110/10(5) mum(2)), and MZL (122/10(5) mum(2)). In contrast, the number of CD8-positive cells (55/10(5) mum(2)) in LCL was significantly lower (p<0.01) compared to B-PSL, FL and MZL. Conclusions: In summary the number of CD8-positive T cells in B-cell lymphoproliferative disorders differs in regard to tumor type and differentiation with lowest numbers in diffuse large B-cell lymphomas. However, due-to anoverlap of the number of TILs, this parameter cannot be employed as a diagnostic parameter for individual cases.

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Documento generato il 29/03/20 alle ore 08:33:03